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The typical PEG-maleimide-thiol reaction results in thiosuccinimide formation which is reversible, with PEG-maleimide elimination occurring slowly under biologically relevant conditions. The reversed reaction leads to the breakage of the maleimide-thiol linkage and the loss of PEG from the thiol/cysteine-containing molecules. If the maleimide-thiol chemistry does not work for your application, you may consider alternatives with […]

A recent review article discussed in details the current status and future prospect of protein pegylation. FDA approved pegylated drugs 2018 source: sciencedirect.com  

Creative PEGWorks is now offering a series of PEG Dendrimers with biodegradable building blocks. Dendrimers are functionalized with amine, acid, azide etc.

Are you looking for a better way to improve your PEGylation yield? I bet you are. What Affects PEGylation Yield? Many parameters affect PEGylation process. The surface accessibility of the reactive site of amino acids is the most critical. On protein surfaces, there exist hydrophobic patches and concaves that expel water and thus hydrophilic PEGs. […]

Liposome Drug Products Chemistry, Manufacturing, and Controls; Human Pharmacokinetics and Bioavailability; and Labeling Documentation Guidance for Industry It provides specific labeling requirements for liposome versus pegylated liposome. The nonproprietary name of a drug product approved under the Federal Food, Drug, and Cosmetic Act is its established name, which , in most instances , will be […]

A short polyethylene glycol (PEG) and its pegylation to small molecules could make a huge difference. Nektar announced positive topline results from an oral Human Abuse Potential (HAP) study of NKTR-181, which is a first-in-class opioid analgesic.  What Is Nektar? NKTR-181 is a pegylated small molecule drug: a short PEG with six repeating ethylene glycol […]

Do you need a special PEG reagent synthesized? You’re in luck! At Creative PEGWorks, we handle custom synthesis services for polyethylene glycol (PEG) and other polymers. Common Custom Synthesis Requests Working with a wide variety of functional groups and a broad range of molecular weights, we frequently provide custom synthesis of: When you’re ready to […]

Benefits of PEGylation in Pharmaceuticals Wondering if you should use PEGylation for your products? There are a number of reasons to start using the PEG polymer, including the following benefits: If you’re looking for a company to handle your PEGylation needs, contact Creative PEG Works, a biotechnology company located in North Carolina. We specialize in […]