This post outlines the fundamental methods for calculating the contour length—the maximum extended chain dimension—and the hydrodynamic radius, which characterizes the effective size of the solvated coil. These calculations rely on established polymer physics and empirical relations from experimental data.
What are ADC linkers & what is on the horizon in the field of ADC research?
Learn about the researchers at MIT that are using PEGs in fluorescent polymer gels to help detect structural failure in energy equipment!
To date, only eleven PEGylated proteins, antibody fragments, oligonucleotides, and small molecules that have been approved by the FDA are on the market. Available PEGylated Drugs This includes PEGylated bovine adenosine deaminase: pegademase bovine (Adagen); and PEGylated l-asparaginase: pegaspargase (Oncaspar); PEGylated products of interferon-alpha (IFN-alpha): peginterferon-2b (PegIntron) and peginterferon-2a (Pegasys); PEGylated granulocyte colony stimulating factor […]
FDA has approved AstraZeneca’s Movantik for opioid-induced constipation in adults with chronic non-cancer pain. Movantik (naloxegol), an oral once-a-day treatment originally developed by Nektar Therapeutics, can decrease the constipating effects of opioids. The drug’s safety and effectiveness were established in two clinical trials. What Is PEGylated Naloxegol? Naloxegol is PEGylated naloxol, which is a peripherally-selective […]
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