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What Are ADC Linkers: Antibody–Drug Conjugates—A Tutorial Review
What are ADC linkers & what is on the horizon in the field of ADC research?
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MIT is Utilizing PEGs in Their Fluorescent Polymer Gels & Stimuli-Responsive Smart Materials
Learn about the researchers at MIT that are using PEGs in fluorescent polymer gels to help detect structural failure in energy equipment!
FDA-Approved PEGylated Drugs
To date, only eleven PEGylated proteins, antibody fragments, oligonucleotides, and small molecules that have been approved by the FDA are on the market. Available PEGylated DrugsThis includes PEGylated bovine adenosine deaminase: pegademase bovine (Adagen); and PEGylated l-asparaginase: pegaspargase (Oncaspar); PEGylated products of interferon-alpha (IFN-alpha): peginterferon-2b (PegIntron) and peginterferon-2a (Pegasys); PEGylated granulocyte colony stimulating factor (GCSF): […]
FDA Approves Constipation Drug PEGylated Naloxol
FDA has approved AstraZeneca’s Movantik for opioid-induced constipation in adults with chronic non-cancer pain. Movantik (naloxegol), an oral once-a-day treatment originally developed by Nektar Therapeutics, can decrease the constipating effects of opioids. The drug’s safety and effectiveness were established in two clinical trials.What Is PEGylated Naloxegol?Naloxegol is PEGylated naloxol, which is a peripherally-selective opioid antagonist. […]