Latest products update, new products introduction, PEG and biopolymer breakthrough research and products news.
Regulatory updates on PEGylated drugs and biopolymer medical devices.
The molecular weight (MW) of hyaluronic acid (HA) can be determined by size-exclusion chromatography coupled with multi-angle light scattering (SEC-MALS), conventional SEC, or intrinsic viscosity. SEC-MALS provides absolute weight-average MW. Conventional SEC and intrinsic viscosity measurements provide a rapid, low-cost alternative MW estimation.
Food and Drug Administration (FDA) has approved seven biosimilars for pegfilgrastim, the active ingredient in the reference product Neulasta (developed by Amgen). Pegfilgrastim is a PEGylated form of granulocyte colony-stimulating factor used to reduce the risk of febrile neutropenia in patients undergoing myelosuppressive chemotherapy.
This post outlines the fundamental methods for calculating the contour length—the maximum extended chain dimension—and the hydrodynamic radius, which characterizes the effective size of the solvated coil. These calculations rely on established polymer physics and empirical relations from experimental data.
PEGylation involves covalently attaching PEG molecules to protein for example, typically at specific functional groups (e.g., lysine residues or N-terminal amines). The degree of PEGylation (number of PEG molecules per protein molecule) or the total mass of PEG attached must be quantified.
Metal-Organic Frameworks – The Royal Swedish Academy of Sciences has decided to award Susumu Kitagawa, Richard Robson, and Omar M. Yaghi the Nobel Prize in Chemistry 2025, for the development of metal–organic frameworks.
PEGylated Metal-Organic Frameworks
Abstract Maleimides are essential compounds for drug conjugation reactions via thiols to antibodies, peptides and other targeting units. However, one main drawback is the occurrence of thiol exchange reactions with, for example, glutathione resulting in loss of the targeting ability. A new strategy to overcome such retro-Michael exchange processes of maleimide–thiol conjugates by stabilization of […]
Learn about antibody drug conjugates (ADCs), including how they’re being used in current methods, trials, and research.
What are ADC linkers & what is on the horizon in the field of ADC research?
This article reviews PEG linkers, their structure, applications, and the many advantages they bring to the world of medicine and science.
PROTACs have the potential to transform the landscape of cancer therapy by targeting specific proteins for degradation. Learn about what they are and why they’re so powerful.
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