This post outlines the fundamental methods for calculating the contour length—the maximum extended chain dimension—and the hydrodynamic radius, which characterizes the effective size of the solvated coil. These calculations rely on established polymer physics and empirical relations from experimental data.
PEGylation involves covalently attaching PEG molecules to protein for example, typically at specific functional groups (e.g., lysine residues or N-terminal amines). The degree of PEGylation (number of PEG molecules per protein molecule) or the total mass of PEG attached must be quantified.
Abstract Maleimides are essential compounds for drug conjugation reactions via thiols to antibodies, peptides and other targeting units. However, one main drawback is the occurrence of thiol exchange reactions with, for example, glutathione resulting in loss of the targeting ability. A new strategy to overcome such retro-Michael exchange processes of maleimide–thiol conjugates by stabilization of […]
Learn about antibody drug conjugates (ADCs), including how they’re being used in current methods, trials, and research.
This article reviews PEG linkers, their structure, applications, and the many advantages they bring to the world of medicine and science.
Click chemistry reagents are essential for facilitating highly selective and reliable reactions. Learn about what they are and how they’re used.
PEGylation is a chemical modification process that involves attaching polyethylene glycol (PEG) molecules to proteins. Learn about what PEGylated proteins are and their applications in today’s world.
The FDA’s consideration of a biosimilar drug could open up biologic drug research. Learn how you can innovate with our PEGylation products!
Nanolipoprotein particles (NLPs), which are mimetics of naturally occurring high-density lipoproteins (HDLs) present in the human body have been suggested as a new delivery platform for a range of therapeutics for cancer chemotherapy, heart disease, and infectious diseases. FDA approved drugs such as immunotherapeutic proteins, single-stranded DNA, small molecule drugs such as doxorubicin can be […]
Creative PEGWorks has collected hundreds of papers published in peer-reviewed journals citing the use of PEG derivatives for PEGylation of proteins, enzymes, antibodies, peptides, biologic, nucleic acids, nanoparticles, chips, surfaces, dendrimers, hydrogels, liposomes and micelles. These papers describe detailed procedures and chemistry reaction conditions as well as experiment characterization data for the use of PEGylation […]
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