AbstractMaleimides are essential compounds for drug conjugation reactions via thiols to antibodies, peptides and other targeting units. However, one main drawback is the occurrence of thiol exchange reactions with, for example, glutathione resulting in loss of the targeting ability. A new strategy to overcome such retro-Michael exchange processes of maleimide–thiol conjugates by stabilization of the […]
Learn about antibody drug conjugates (ADCs), including how they’re being used in current methods, trials, and research.
This article reviews PEG linkers, their structure, applications, and the many advantages they bring to the world of medicine and science.
Click chemistry reagents are essential for facilitating highly selective and reliable reactions. Learn about what they are and how they’re used.
PEGylation is a chemical modification process that involves attaching polyethylene glycol (PEG) molecules to proteins. Learn about what PEGylated proteins are and their applications in today’s world.
The FDA’s consideration of a biosimilar drug could open up biologic drug research. Learn how you can innovate with our PEGylation products!
Nanolipoprotein particles (NLPs), which are mimetics of naturally occurring high-density lipoproteins (HDLs) present in the human body have been suggested as a new delivery platform for a range of therapeutics for cancer chemotherapy, heart disease, and infectious diseases. FDA approved drugs such as immunotherapeutic proteins, single-stranded DNA, small molecule drugs such as doxorubicin can be […]
Creative PEGWorks has collected hundreds of papers published in peer-reviewed journals citing the use of PEG derivatives for PEGylation of proteins, enzymes, antibodies, peptides, biologic, nucleic acids, nanoparticles, chips, surfaces, dendrimers, hydrogels, liposomes and micelles. These papers describe detailed procedures and chemistry reaction conditions as well as experiment characterization data for the use of PEGylation […]
A research group from the Republic of Korea developed poly(ethylene glycol)-conjugated hyaluronic acid nanoparticles (PEG-HANPs) with high tumor targetability. Doxorubicin (DOX) was chosen as the model anticancer drug and was effectively encapsulated into the mineralized nanoparticles. How PEGylated Drugs Impact Cancer Research“The most effective antitumor efficacy was observed for DOX-loaded PEG-HANPs. Overall, these results suggest […]
Creative PEGWorks developed a series of amphiphilic, surfactant-like PEG derivatives and they are now available for purchase online. PEG surfactants and pegylated lipids can be used for drug delivery and formulation, to enhance drug solubility, improve bioavailability and pharmacokinetics, enable targeting cell receptors, and amplify imaging signals. PEGs in Drug Delivery & FormulationSuccessful examples of […]
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