PEGylation Reagents - Creative PEGWorks

PEGylated Nanoparticle Technologies: Mechanisms and Therapeutic Applications – Liposome, Lipid Nanoparticle, Polymeric Micelles

PEGylated nanoparticles from liposome systems to advanced polymeric and lipid platforms tailored to specific therapeutic payloads and administration routes. Polyethylene glycol (PEG) surface modification, or PEGylation, constitutes a foundational strategy in nanomedicine for enhancing the pharmacokinetic and pharmacodynamic profiles of nanoparticle-based drug delivery systems.

April 16, 2026 Categories

Calculating the Contour Length and Hydrodynamic Radius of Polyethylene Glycol in Aqueous Solutions

This post outlines the fundamental methods for calculating the contour length—the maximum extended chain dimension—and the hydrodynamic radius, which characterizes the effective size of the solvated coil. These calculations rely on established polymer physics and empirical relations from experimental data.

December 9, 2025 Categories

Quantify PEG attached to protein or nanoparticle with the 5 validated methods you can rely on!

PEGylation involves covalently attaching PEG molecules to protein for example, typically at specific functional groups (e.g., lysine residues or N-terminal amines). The degree of PEGylation (number of PEG molecules per protein molecule) or the total mass of PEG attached must be quantified.

October 8, 2025 Categories

Model system for the transcyclization reaction.

Improving the Stability of Maleimide–Thiol Conjugation for Drug Targeting

Abstract Maleimides are essential compounds for drug conjugation reactions via thiols to antibodies, peptides and other targeting units. However, one main drawback is the occurrence of thiol exchange reactions with, for example, glutathione resulting in loss of the targeting ability. A new strategy to overcome such retro-Michael exchange processes of maleimide–thiol conjugates by stabilization of […]

January 24, 2024 Categories

Illustration of an ADC binding to a cell-surface antigen.

ADC Linkers: An Assurance for Controlled Delivery of Antibody Drug Conjugate

Learn about antibody drug conjugates (ADCs), including how they’re being used in current methods, trials, and research.

January 17, 2024 Categories

Picture of a person looking through a microscope at a reaction with PEG linkers.

What Are PEG Linkers?

This article reviews PEG linkers, their structure, applications, and the many advantages they bring to the world of medicine and science.

November 8, 2023 Categories

Illustration of click chemistry reagents.

Types of Click Chemistry Reagents

Click chemistry reagents are essential for facilitating highly selective and reliable reactions. Learn about what they are and how they’re used.

October 25, 2023 PEGylation Reagents

Picture of a person holding up a 3D model of a molecule for the article about PEGylated proteins.

What are PEGylated Proteins?

PEGylation is a chemical modification process that involves attaching polyethylene glycol (PEG) molecules to proteins. Learn about what PEGylated proteins are and their applications in today’s world.

October 18, 2023 Categories

Picture of a woman working with biosimilar drugs and PEGylation service products

Is a PEGylated Protein Considered a Biobetter Biologic or Biosimilar Drug?

The FDA’s consideration of a biosimilar drug could open up biologic drug research. Learn how you can innovate with our PEGylation products!

December 1, 2022 Categories

High-Density Lipoprotein Mimetic Drug Delivery Systems for Cancer, Cardiovascular Diseases

Nanolipoprotein particles (NLPs), which are mimetics of naturally occurring high-density lipoproteins (HDLs) present in the human body have been suggested as a new delivery platform for a range of therapeutics for cancer chemotherapy, heart disease, and infectious diseases. FDA approved drugs such as immunotherapeutic proteins, single-stranded DNA, small molecule drugs such as doxorubicin can be […]

September 28, 2014 Categories