When PEG chains are densely grafted as side chains along a polymer backbone—they adopt an extended “brush” conformation. This conformational change dramatically improves protein resistance, reduces nonspecific cellular uptake, and can mitigate recognition by anti-PEG antibodies. It is a powerful new took to achieve stealth, circulation and immunity.
Poly(ethylene glycol)-norbornene, commonly called PEG-norbornene or PEGNB, has become one of the most useful macromers in modern biomaterials chemistry. It enables rapid, orthogonal, and highly cytocompatible hydrogel formation through thiol-norbornene (thiol-ene) click chemistry.
PEGylation, the covalent attachment of polyethylene glycol (PEG) chains to therapeutic molecules, has evolved from a laboratory innovation in the 1970s into a mature, commercially validated technology essential to modern biopharmaceuticals. Its development reflects progressive improvements in polymer chemistry, conjugation techniques, and manufacturing scale-up.
Food and Drug Administration (FDA) has approved seven biosimilars for pegfilgrastim, the active ingredient in the reference product Neulasta (developed by Amgen). Pegfilgrastim is a PEGylated form of granulocyte colony-stimulating factor used to reduce the risk of febrile neutropenia in patients undergoing myelosuppressive chemotherapy.
This post outlines the fundamental methods for calculating the contour length—the maximum extended chain dimension—and the hydrodynamic radius, which characterizes the effective size of the solvated coil. These calculations rely on established polymer physics and empirical relations from experimental data.
PEGylation involves covalently attaching PEG molecules to protein for example, typically at specific functional groups (e.g., lysine residues or N-terminal amines). The degree of PEGylation (number of PEG molecules per protein molecule) or the total mass of PEG attached must be quantified.
Metal-Organic Frameworks – The Royal Swedish Academy of Sciences has decided to award Susumu Kitagawa, Richard Robson, and Omar M. Yaghi the Nobel Prize in Chemistry 2025, for the development of metal–organic frameworks.
PEGylated Metal-Organic Frameworks
The FDA’s consideration of a biosimilar drug could open up biologic drug research. Learn how you can innovate with our PEGylation products!
Learn about the researchers at MIT that are using PEGs in fluorescent polymer gels to help detect structural failure in energy equipment!
A deep dive into anti-PEG antibodies, how they could affect the performance of medicines, and how Creative PEGWorks can help your pharmaceutical projects.
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