PEGylation involves covalently attaching PEG molecules to protein for example, typically at specific functional groups (e.g., lysine residues or N-terminal amines). The degree of PEGylation (number of PEG molecules per protein molecule) or the total mass of PEG attached must be quantified.
Metal-Organic Frameworks – The Royal Swedish Academy of Sciences has decided to award Susumu Kitagawa, Richard Robson, and Omar M. Yaghi the Nobel Prize in Chemistry 2025, for the development of metal–organic frameworks.
PEGylated Metal-Organic Frameworks
The FDA’s consideration of a biosimilar drug could open up biologic drug research. Learn how you can innovate with our PEGylation products!
Learn about the researchers at MIT that are using PEGs in fluorescent polymer gels to help detect structural failure in energy equipment!
A deep dive into anti-PEG antibodies, how they could affect the performance of medicines, and how Creative PEGWorks can help your pharmaceutical projects.
Our Multi-Arm PEG Products4-Arm PEG-X/YBifunctional 4-Arm PEG reagents have two functional groups X/Y with 1:3 ratio or 2:2 ratio. We started offering this series of special reagents as customs synthesis with the following combinations. We are also listing some of these reagents as regular catalog products that are ready to ship overnight.We offer three ratios […]
The typical PEG-maleimide-thiol reaction results in thiosuccinimide formation which is reversible, with PEG-maleimide elimination occurring slowly under biologically relevant conditions. The reversed reaction leads to the breakage of the maleimide-thiol linkage and the loss of PEG from the thiol/cysteine-containing molecules. If the maleimide-thiol chemistry does not work for your application, you may consider alternatives with […]
A recent review article discussed in details the current status and future prospect of protein pegylation. FDA approved pegylated drugs 2018 source: sciencedirect.com
Creative PEGWorks is now offering a series of PEG Dendrimers with biodegradable building blocks. Dendrimers are functionalized with amine, acid, azide etc.
Are you looking for a better way to improve your PEGylation yield? I bet you are. What Affects PEGylation Yield?Many parameters affect PEGylation process. The surface accessibility of the reactive site of amino acids is the most critical. On protein surfaces, there exist hydrophobic patches and concaves that expel water and thus hydrophilic PEGs. Reactive […]
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