Background on Creative PEGWorks website - leading PEG supplier.


Bifunctional Multi-Arm PEG Products

Our Multi-Arm PEG Products 4-Arm PEG-X/Y Bifunctional 4-Arm PEG reagents have two functional groups X/Y with 1:3 ratio or 2:2 ratio. We started offering this series of special reagents as customs synthesis with the following combinations. We are also listing some of these reagents as regular catalog products that are ready to ship overnight. We […]

Is Your Maleimide Thiol Chemistry Stable?

The typical PEG-maleimide-thiol reaction results in thiosuccinimide formation which is reversible, with PEG-maleimide elimination occurring slowly under biologically relevant conditions. The reversed reaction leads to the breakage of the maleimide-thiol linkage and the loss of PEG from the thiol/cysteine-containing molecules. If the maleimide-thiol chemistry does not work for your application, you may consider alternatives with […]

The Case for Protein PEGylation

A recent review article discussed in details the current status and future prospect of protein pegylation. FDA approved pegylated drugs 2018 source:  

Biodegradable PEG Dendrimers

Creative PEGWorks is now offering a series of PEG Dendrimers with biodegradable building blocks. Dendrimers are functionalized with amine, acid, azide etc.

Looking for a better method to improve your PEGylation yield?

Are you looking for a better way to improve your PEGylation yield? I bet you are. What Affects PEGylation Yield? Many parameters affect PEGylation process. The surface accessibility of the reactive site of amino acids is the most critical. On protein surfaces, there exist hydrophobic patches and concaves that expel water and thus hydrophilic PEGs. […]

FDA Latest Industry Guidance for Liposome Drug Products

Liposome Drug Products Chemistry, Manufacturing, and Controls; Human Pharmacokinetics and Bioavailability; and Labeling Documentation Guidance for Industry It provides specific labeling requirements for liposome versus pegylated liposome. The nonproprietary name of a drug product approved under the Federal Food, Drug, and Cosmetic Act is its established name, which , in most instances , will be […]

Nektar – PEGylated Opioid Analgesic Reported Positive Phase 3 Clinical Trial Results

A short polyethylene glycol (PEG) and its pegylation to small molecules could make a huge difference. Nektar announced positive topline results from an oral Human Abuse Potential (HAP) study of NKTR-181, which is a first-in-class opioid analgesic.  What Is Nektar? NKTR-181 is a pegylated small molecule drug: a short PEG with six repeating ethylene glycol […]