PEGylation, the covalent attachment of polyethylene glycol (PEG) chains to therapeutic molecules, has evolved from a laboratory innovation in the 1970s into a mature, commercially validated technology essential to modern biopharmaceuticals. Its development reflects progressive improvements in polymer chemistry, conjugation techniques, and manufacturing scale-up.
Food and Drug Administration (FDA) has approved seven biosimilars for pegfilgrastim, the active ingredient in the reference product Neulasta (developed by Amgen). Pegfilgrastim is a PEGylated form of granulocyte colony-stimulating factor used to reduce the risk of febrile neutropenia in patients undergoing myelosuppressive chemotherapy.
This post outlines the fundamental methods for calculating the contour length—the maximum extended chain dimension—and the hydrodynamic radius, which characterizes the effective size of the solvated coil. These calculations rely on established polymer physics and empirical relations from experimental data.
PEGylation involves covalently attaching PEG molecules to protein for example, typically at specific functional groups (e.g., lysine residues or N-terminal amines). The degree of PEGylation (number of PEG molecules per protein molecule) or the total mass of PEG attached must be quantified.
Metal-Organic Frameworks – The Royal Swedish Academy of Sciences has decided to award Susumu Kitagawa, Richard Robson, and Omar M. Yaghi the Nobel Prize in Chemistry 2025, for the development of metal–organic frameworks.
PEGylated Metal-Organic Frameworks
The FDA’s consideration of a biosimilar drug could open up biologic drug research. Learn how you can innovate with our PEGylation products!
Learn about the researchers at MIT that are using PEGs in fluorescent polymer gels to help detect structural failure in energy equipment!
A deep dive into anti-PEG antibodies, how they could affect the performance of medicines, and how Creative PEGWorks can help your pharmaceutical projects.
Our Multi-Arm PEG Products 4-Arm PEG-X/Y Bifunctional 4-Arm PEG reagents have two functional groups X/Y with 1:3 ratio or 2:2 ratio. We started offering this series of special reagents as customs synthesis with the following combinations. We are also listing some of these reagents as regular catalog products that are ready to ship overnight. We […]
The typical PEG-maleimide-thiol reaction results in thiosuccinimide formation which is reversible, with PEG-maleimide elimination occurring slowly under biologically relevant conditions. The reversed reaction leads to the breakage of the maleimide-thiol linkage and the loss of PEG from the thiol/cysteine-containing molecules. If the maleimide-thiol chemistry does not work for your application, you may consider alternatives with […]
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