Food and Drug Administration (FDA) has approved seven biosimilars for pegfilgrastim, the active ingredient in the reference product Neulasta (developed by Amgen). Pegfilgrastim is a PEGylated form of granulocyte colony-stimulating factor used to reduce the risk of febrile neutropenia in patients undergoing myelosuppressive chemotherapy.
This post outlines the fundamental methods for calculating the contour length—the maximum extended chain dimension—and the hydrodynamic radius, which characterizes the effective size of the solvated coil. These calculations rely on established polymer physics and empirical relations from experimental data.
This article reviews PEG linkers, their structure, applications, and the many advantages they bring to the world of medicine and science.
Phospholipids are an essential class of molecules that play a pivotal role in the structure and function of biological membranes. Learn about these molecules and how they function.
Learn about some common applications of hydrogels in the field of biochemistry—as well as some predictions about where they may be in the future.Â
The FDA’s consideration of a biosimilar drug could open up biologic drug research. Learn how you can innovate with our PEGylation products!
Learn more about how PEGs can be used to optimize gene editing and systemic gene delivery.
In November 2015, the Food and Drug Administration approved the use of Amgen’s pegfilgrastim (Neulasta) to increase the survival of people acutely exposed to high-dose radiation that damages the bone marrow, which will improve access to the drug in the event of a public health emergency such as a nuclear power plant accident or terrorist […]
Pegfilgrastim is a PEGylated form of the recombinant human granulocyte colony-stimulating factor analog filgrastim. It serves to stimulate the level of white blood cells. Pegfilgrastim has a human half-life of 15 to 80 hours, much longer than the parent filgrastim (3–4 hours). Pharma Companies & PEGylated Drug Development Multiple major pharma companies have been busy […]
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