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ADC Linkers: An Assurance for Controlled Delivery of Antibody Drug Conjugate
Learn about antibody drug conjugates (ADCs), including how they’re being used in current methods, trials, and research.
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What Are ADC Linkers: Antibody–Drug Conjugates—A Tutorial Review
What are ADC linkers & what is on the horizon in the field of ADC research?
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What Is PEG Aldehyde?
Explore the world of PEG aldehyde, delving into its properties, various applications, and the safety considerations surrounding its use.
FDA Approves Constipation Drug PEGylated Naloxol
FDA has approved AstraZeneca’s Movantik for opioid-induced constipation in adults with chronic non-cancer pain. Movantik (naloxegol), an oral once-a-day treatment originally developed by Nektar Therapeutics, can decrease the constipating effects of opioids. The drug’s safety and effectiveness were established in two clinical trials. What Is PEGylated Naloxegol? Naloxegol is PEGylated naloxol, which is a peripherally-selective […]
High-Density Lipoprotein Mimetic Drug Delivery Systems for Cancer, Cardiovascular Diseases
Nanolipoprotein particles (NLPs), which are mimetics of naturally occurring high-density lipoproteins (HDLs) present in the human body have been suggested as a new delivery platform for a range of therapeutics for cancer chemotherapy, heart disease, and infectious diseases. FDA approved drugs such as immunotherapeutic proteins, single-stranded DNA, small molecule drugs such as doxorubicin can be […]
PEGylation Protocols and Literature References
Creative PEGWorks has collected hundreds of papers published in peer-reviewed journals citing the use of PEG derivatives for PEGylation of proteins, enzymes, antibodies, peptides, biologic, nucleic acids, nanoparticles, chips, surfaces, dendrimers, hydrogels, liposomes and micelles. These papers describe detailed procedures and chemistry reaction conditions as well as experiment characterization data for the use of PEGylation […]
PEGylated Hyaluronic Acid Nanoparticle Drug Delivery
A research group from the Republic of Korea developed poly(ethylene glycol)-conjugated hyaluronic acid nanoparticles (PEG-HANPs) with high tumor targetability. Doxorubicin (DOX) was chosen as the model anticancer drug and was effectively encapsulated into the mineralized nanoparticles. How PEGylated Drugs Impact Cancer Research “The most effective antitumor efficacy was observed for DOX-loaded PEG-HANPs. Overall, these results […]
Surfactant-like PEG Derivatives for Drug Delivery
Creative PEGWorks developed a series of amphiphilic, surfactant-like PEG derivatives and they are now available for purchase online. PEG surfactants and pegylated lipids can be used for drug delivery and formulation, to enhance drug solubility, improve bioavailability and pharmacokinetics, enable targeting cell receptors, and amplify imaging signals. PEGs in Drug Delivery & Formulation Successful examples […]
Fluorescent or Radioactive PEG-like Nanoprobes
Researchers from the Massachusetts General Hospital and Harvard Medical School developed the novel, “PEG-like Nanoprobes,’’ with controllable pharmacokinetics and tunable fluorescence. The “PEG-like Nanoprobes’’ nanoparticles feature a unique design where a single PEG polymer surrounds a short fluorochrome and radiometal bearing peptide, and endows the resulting nanoprobe with pharmacokinetic control (based on the molecular weight […]
Designer Proteins Trigger Cell Death – a new cancer therapy?
Researchers from the University of Washington and the Howard Hughes Medical Institute use an innovative computational design approach coupled with in-vitro-targeted evolution to produce a potent polypeptide inhibitor that triggers apoptosis of virus-infected cancer cells, suppresses tumor growth, and extends survival in a xenograft model of EBV-positive human lymphoma. How Designer Proteins Impact Cancer Research […]