When PEG chains are densely grafted as side chains along a polymer backbone—they adopt an extended “brush” conformation. This conformational change dramatically improves protein resistance, reduces nonspecific cellular uptake, and can mitigate recognition by anti-PEG antibodies. It is a powerful new took to achieve stealth, circulation and immunity.
This post outlines the fundamental methods for calculating the contour length—the maximum extended chain dimension—and the hydrodynamic radius, which characterizes the effective size of the solvated coil. These calculations rely on established polymer physics and empirical relations from experimental data.
Metal-Organic Frameworks – The Royal Swedish Academy of Sciences has decided to award Susumu Kitagawa, Richard Robson, and Omar M. Yaghi the Nobel Prize in Chemistry 2025, for the development of metal–organic frameworks.
PEGylated Metal-Organic Frameworks
Learn about antibody drug conjugates (ADCs), including how they’re being used in current methods, trials, and research.
What are ADC linkers & what is on the horizon in the field of ADC research?
Explore the world of PEG aldehyde, delving into its properties, various applications, and the safety considerations surrounding its use.
FDA has approved AstraZeneca’s Movantik for opioid-induced constipation in adults with chronic non-cancer pain. Movantik (naloxegol), an oral once-a-day treatment originally developed by Nektar Therapeutics, can decrease the constipating effects of opioids. The drug’s safety and effectiveness were established in two clinical trials. What Is PEGylated Naloxegol? Naloxegol is PEGylated naloxol, which is a peripherally-selective […]
Nanolipoprotein particles (NLPs), which are mimetics of naturally occurring high-density lipoproteins (HDLs) present in the human body have been suggested as a new delivery platform for a range of therapeutics for cancer chemotherapy, heart disease, and infectious diseases. FDA approved drugs such as immunotherapeutic proteins, single-stranded DNA, small molecule drugs such as doxorubicin can be […]
Creative PEGWorks has collected hundreds of papers published in peer-reviewed journals citing the use of PEG derivatives for PEGylation of proteins, enzymes, antibodies, peptides, biologic, nucleic acids, nanoparticles, chips, surfaces, dendrimers, hydrogels, liposomes and micelles. These papers describe detailed procedures and chemistry reaction conditions as well as experiment characterization data for the use of PEGylation […]
A research group from the Republic of Korea developed poly(ethylene glycol)-conjugated hyaluronic acid nanoparticles (PEG-HANPs) with high tumor targetability. Doxorubicin (DOX) was chosen as the model anticancer drug and was effectively encapsulated into the mineralized nanoparticles. How PEGylated Drugs Impact Cancer Research “The most effective antitumor efficacy was observed for DOX-loaded PEG-HANPs. Overall, these results […]
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