PEG Library

Our PEG library contains landmark reference books, book chapters, review articles about PEGylation chemistry, PEG reagent protocol, hyaluronic acid and polysaccharide applications.

PEG Library & References

PEGYLATION CHEMISTRY AND PEG REAGENT SELECTION GUIDE  – This document is intended to help researchers select proper PEGylation reagents to achieve desired properties and applications.


1. The Case for Protein PEGylation, Engineering of Biomaterials for Drug Delivery Systems, 2018. Text.

2. Therapeutic Proteins: Strategies to Modulate Their Plasma Half-lives, Ed. Roland Kontermann, Wiley-Blackwell, 2012; Part Two, Page 41-56, Half-Life Extension Through PEGylation. Text.

3. Kang Choon Lee, Seulki Lee, What is the future of pegylated therapies? Expert Opin Emerg Drugs, 2015; 20(4): 531–536. Text.

4. Jevsevar et al, PEGylation of Therapeutic Proteins, Biotechnol. J. 2010, 5, 113–128. Text.

5. Peter L Turecek, Mary J Bossard, Freddy Schoetens, Inge A Ivens, PEGylation of Biopharmaceuticals: A Review of Chemistry and Nonclinical Safety Information of Approved Drugs, Journal of Pharmaceutical Sciences, 2016, 105, 460-475. Text.

6. Liu et al, Current Drug Research on PEGylation with Small Molecule Agents, Progress in Polymer Science, 2013, 38, 421-444. Text.

7. Gambhir et al, Nanoparticle PEGylation for Imaging and Therapy, Nanomedicine, 2011, 6(4): 715-728. Text.

8. Fishburn et al, The Pharmacology of PEGylation: Balancing PD with PK to Generate Novel Therapeutics. Journal of Pharmaceutical Sciences, 2008, 97: 4167-4183. Text.

9. Veronese et al, PEGylation: Successful Approach to Drug Delivery, Drug Discovery Today, 2005, 10(21): 1451-1458. Text.

10. Kataoka et al, PEGylated Nanoparticles for Biological and Pharmaceutical Applications, Advanced Drug Delivery Reviews, 2003, 55: 403-419. Text.

11 Harris et al, Chemistry for Peptide and Protein PEGylation, Advanced Drug Delivery Reviews, 2002, 54: 459-476. Text.

12. J Milton Harris, Effect of PEGylation on Pharmaceuticals, Nature Reviews Drug Discovery, 2003, 2, 214-221, doi:10.1038/nrd1033. Text.

13. Jim Kling, PEGylation of Biologics, BioProcess International, Vol. 11, No. 3, March 2013, pp. 34?3. Text.

14. Francesco M. Veronese, Peptide and Protein PEGylation: a Review of Problems and Solutions, Biomaterials, 2001, 22(5): 405-417. Text.


Please visit PEGylation Literature to select proper procedures and protocols for PEGylation chemistry.


1. Unsaturated and thiolated derivatives of polysaccharides as functional matrixes for tissue engineering and pharmacology: A review, Carbohydrate Polymers 259 (2021) 117735, Text.

2. Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications, Biotechnology Letters, 2007, 29(1): 17-25. Text.

3. Novel drug development opportunities for heparin, Nature Review Drug Discovery, 2002, 1(2): 140-148. Text.

4. Alginate: Properties and biomedical applications, Progress in Polymer Science, 2012, 37(1): 106-126. Text.

5. Dextran for targeted and sustained delivery of therapeutic and imaging agents, Journal of Controlled Release, 2012, 69(1): 1-25. Text.

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