Food and Drug Administration (FDA) has approved seven biosimilars for pegfilgrastim, the active ingredient in the reference product Neulasta (developed by Amgen). Pegfilgrastim is a PEGylated form of granulocyte colony-stimulating factor used to reduce the risk of febrile neutropenia in patients undergoing myelosuppressive chemotherapy.
This post outlines the fundamental methods for calculating the contour length—the maximum extended chain dimension—and the hydrodynamic radius, which characterizes the effective size of the solvated coil. These calculations rely on established polymer physics and empirical relations from experimental data.
PEGylation involves covalently attaching PEG molecules to protein for example, typically at specific functional groups (e.g., lysine residues or N-terminal amines). The degree of PEGylation (number of PEG molecules per protein molecule) or the total mass of PEG attached must be quantified.
Metal-Organic Frameworks – The Royal Swedish Academy of Sciences has decided to award Susumu Kitagawa, Richard Robson, and Omar M. Yaghi the Nobel Prize in Chemistry 2025, for the development of metal–organic frameworks.
PEGylated Metal-Organic Frameworks
Abstract Maleimides are essential compounds for drug conjugation reactions via thiols to antibodies, peptides and other targeting units. However, one main drawback is the occurrence of thiol exchange reactions with, for example, glutathione resulting in loss of the targeting ability. A new strategy to overcome such retro-Michael exchange processes of maleimide–thiol conjugates by stabilization of […]
This article reviews PEG linkers, their structure, applications, and the many advantages they bring to the world of medicine and science.
PEGylation is a chemical modification process that involves attaching polyethylene glycol (PEG) molecules to proteins. Learn about what PEGylated proteins are and their applications in today’s world.
The FDA’s consideration of a biosimilar drug could open up biologic drug research. Learn how you can innovate with our PEGylation products!
Learn more about how PEGs can be used to optimize gene editing and systemic gene delivery.
A deep dive into anti-PEG antibodies, how they could affect the performance of medicines, and how Creative PEGWorks can help your pharmaceutical projects.
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