PEGylation Tools

PEGylation Protocols and Literature References

Creative PEGWorks has collected hundreds of papers published in peer-reviewed journals citing the use of PEG derivatives for PEGylation of proteins, enzymes, antibodies, peptides, biologic, nucleic acids, nanoparticles, chips, surfaces, dendrimers, hydrogels, liposomes and micelles. These paper describe detailed procedures and chemistry reaction conditions as well as experiment characterization data for the use of PEGylation […]

Surfactant-like PEG derivatives for drug delivery

Creative PEGWorks developed a series of amphiphilic, surfactant-like PEG derivatives and they are now available for purchase at www.creativepegworks.com. PEG surfactants and pegylated lipids can be used for drug delivery and formulation, to enhance drug solubility, improve bioavailability and pharmacokinetics, enable targeting cell receptors, and amplify imaging signals. Successful examples include pegylated liposome (Doxil), and […]

Fluorescent or Radioactive PEG-like Nanoprobes

Researchers from the Massachusetts General Hospital and Harvard Medical School developed novel “PEG-like Nanoprobes’’ with controllable pharmacokinetics and  tunable fluorescence. The “PEG-like Nanoprobes’’ nanoparticles feature a unique design where a single PEG polymer surrounds a short fluorochrome and radiometal bearing peptide, and endows the resulting nanoprobe with pharmacokinetic control (based on molecular weight of the […]