FDA-Approved PEGylated Drugs & Their Uses 1. Plegridy (Biogen 2014) PEGylated Interferon Beta-1a for the treatment of patients with relapsing forms of multiple sclerosis. 2. Naloxegol (Movantik) (AstraZeneca 2014) PEGylated naloxol for the treatment of opioid-induced constipation in adults patients with chronic non-cancer pain. 3. Pegnesatide (Omontys) (Takeda Pharmaceuticals, 2012) To treat anemia associated with […]
Hydrogels have gained significant attention as ideal delivery vehicles for protein drugs. However, the use of hydrogels for protein delivery has been restricted because their porous structures inevitably cause a premature leakage of encapsulated proteins. PEG Hydrogels in Biomedical Applications A simple yet effective approach was recently reported to regulate the protein release kinetics of […]
References for Hyaluronic Acid and Heparin Drug Delivery System 1. Hyaluronic Acid 2. Hyaluronate Fluorescein or FITC-labeled hyaluronan 3. Hyaluronate Rhodamine 4. Heparin Rhodamine
The Lai lab at UNC Chapel Hill published an article in Molecular Pharmaceiuticals – Evading Immune Cell Uptake and Clearance Requires PEG Grafting at Densities Substantially Exceeding the Minimum for Brush Conformation. Mol. Pharmaceutics, 2014, 11 (4), pp 1250–1258, DOI: 10.1021/mp400703d. Exploration in PEG Grafting This paper critically pointed out: Coating nanoparticles with polyethylene glycol […]
PEG Therapy Since PEG molecules bind to amino acids to target proteins, they are now being used in the Rheumatology field. For patients with Rheumatoid Arthritis who do not respond to standard treatment, the use of TNF-a inhibitors have been used as an alternative treatment. Positive signs with using this alternative treatment with a reduction […]
To date, only eleven PEGylated proteins, antibody fragments, oligonucleotides, and small molecules that have been approved by the FDA are on the market. Available PEGylated Drugs This includes PEGylated bovine adenosine deaminase: pegademase bovine (Adagen); and PEGylated l-asparaginase: pegaspargase (Oncaspar); PEGylated products of interferon-alpha (IFN-alpha): peginterferon-2b (PegIntron) and peginterferon-2a (Pegasys); PEGylated granulocyte colony stimulating factor […]
Order PEG Products Online Creative PEGWorks set up a Merchant account on amazon.com to make the purchase of PEG products and PEG derivatives easier and faster. You can take advantage of your existing Amazon customer account to directly place orders! On amazon.com, customers can also place orders for other biopolymer products offered by Creative PEGWorks […]
Polysaccharide Product It turns out that shellfish are much more than delicious appetizers or entrees at our seafood restaurant. Scientists can take sugar from the hard outer skeleton of shellfish, including crab, lobster, and shrimp and use it in medicine! This sugar is called chitosan, and it has a variety of great uses. It can […]
Quantum Dots Semiconductor nanocrystals, also known as quantum dots, have a wide range of applications for many industries. Two of the most important applications for them are ink and in the medical industry. The particles emit distinctly different colors when they are reduced in size, and can be incorporated in materials as a sort of […]
Pegylation Pegylation has achieved reasonable success on the market thus far: approximately one dozen PEGylated pharmaceuticals are currently on the market with FDA approval. One of those has been instrumental in fighting the deleterious effects of Growth Hormone Deficiency. Peg acrylate More commonly recognized as a banned substance in professional sports, Human Growth Hormone (HGH) […]
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