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Marketed PEGylated Drugs

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Marketed PEGylated Drugs Approved by FDA and in Europe

An excellent review article is published by scientists from Nektar Therapeutics, Bayer, Jansen, and Baxalta Innovations GmbH in the journal of Journal of Pharmaceutical Sciences. http://dx.doi.org/10.1016/j.xphs.2015.11.015 Journal of Pharmaceutical Sciences 105 (2016) 460-475 “PEGylation of Biopharmaceuticals: A Review of Chemistry andNonclinical Safety Information of Approved Drugs”.    Since 1990, 12 PEGylated biopharmaceuticals have been introduced […]

Custom Synthesis Options at Creative PEGWorks

Do you need a special PEG reagent synthesized? You’re in luck! At Creative PEGWorks, we handle custom synthesis services for polyethylene glycol (PEG) and other polymers. Common Custom Synthesis Requests Working with a wide variety of functional groups and a broad range of molecular weights, we frequently provide custom synthesis of: When you’re ready to […]

Benefits of PEGylation in the Pharmaceutical Industry

Benefits of PEGylation in Pharmaceuticals Wondering if you should use PEGylation for your products? There are a number of reasons to start using the PEG polymer, including the following benefits: If you’re looking for a company to handle your PEGylation needs, contact Creative PEG Works, a biotechnology company located in North Carolina. We specialize in […]

Novel PEG hydrogel as 3D synthetic extracellular matrix (ECM) for organoid culture

A recent article published in the leading scientific journal of Nature (Designer matrices for intestinal stem cell and organoid culture, Matthias P. Lutolf et al from the Ecole Polytechnique Fédérale de Lausanne (EPFL) in Switzerland, Nature, Published online 16 November 2016,  doi:10.1038/nature20168) reported the first intestinal and colorectal cancer organoid culture in fully defined extracellular matrix […]

The Importance of Quality PEG Supplies

As a company that values your PEG products and is concerned about the quality of what you produce, it’s important that you use only the best PEG supplies. It can be difficult to find supplies and materials that are affordable but meet your quality standards. At Creative PEGWorks, we know the importance of quality supplies […]

Best Practices Found in Good Laboratories

The Best Laboratory Practices Certain aspects can get lost in the shuffle when performing day-to-day tasks, especially when you work in an environment that juggles various tasks like a laboratory. That is why having a set of practices is so important. Here are a few of the best practices you will find in the best […]

How Surfactant PEGs Are Helping the Drug Industry

Poly and Acrylamide Allow Drugs to Reach Their Target Faster Many people who experience illnesses that require huge doses of drugs often have trouble entering the bloodstream. Researchers have figured out a way to ease this process by utilizing Poly and Acrylamide. These biocompatible polymers are water soluble and have the ability to stabilize water-repelling […]

The next stop for PEGylated protein drugs: Biosimilar

Pegfilgrastim is a PEGylated form of the recombinant human granulocyte colony-stimulating factor analog filgrastim. It serves to stimulate the level of white blood cells. Pegfilgrastim has a human half-life of 15 to 80 hours, much longer than the parent filgrastim (3–4 hours). Pharma Companies & PEGylated Drug Development Multiple major pharma companies have been busy […]

FDA Guidelines on PEGylated Protein Drug Immunogenicity

Immune responses to therapeutic protein products may pose problems for both patient safety and product efficacy. Immunologically based adverse events, such as anaphylaxis, cytokine release syndrome, and cross-reactive neutralization of endogenous proteins mediating critical functions, have caused sponsors to terminate the development of what otherwise may have been efficacious therapeutic protein products. Potential Effects of […]