Latest products update, new products introduction, PEG and biopolymer breakthrough research and products news.
Regulatory updates on PEGylated drugs and biopolymer medical devices.
Quantum Dots Semiconductor nanocrystals, also known as quantum dots, have a wide range of applications for many industries. Two of the most important applications for them are ink and in the medical industry. The particles emit distinctly different colors when they are reduced in size, and can be incorporated in materials as a sort of […]
Pegylation Pegylation has achieved reasonable success on the market thus far: approximately one dozen PEGylated pharmaceuticals are currently on the market with FDA approval. One of those has been instrumental in fighting the deleterious effects of Growth Hormone Deficiency. Peg acrylate More commonly recognized as a banned substance in professional sports, Human Growth Hormone (HGH) […]
Natural Polysaccharides One of the most exciting fields of medicine today is not on the direct patient contact side of the aisle. The research that is being done using Natural polysaccharides and carbohydrates is bound to change the world of modern medicine for good. Many of the changes that will erupt have yet to be […]
What Is a Biopolymer?A biopolymer is a polymer produced by living organisms, such as DNA and proteins, that are made of repetitive units called monomers.Where Are Biopolymers Found?Biopolymers are essential to every living organism. For example, cellulose, a biopolymer, is the most common organic compound on Earth and accounts for 33% of all plant matter.How […]
FDA has approved AstraZeneca’s Movantik for opioid-induced constipation in adults with chronic non-cancer pain. Movantik (naloxegol), an oral once-a-day treatment originally developed by Nektar Therapeutics, can decrease the constipating effects of opioids. The drug’s safety and effectiveness were established in two clinical trials.What Is PEGylated Naloxegol?Naloxegol is PEGylated naloxol, which is a peripherally-selective opioid antagonist. […]
Nanolipoprotein particles (NLPs), which are mimetics of naturally occurring high-density lipoproteins (HDLs) present in the human body have been suggested as a new delivery platform for a range of therapeutics for cancer chemotherapy, heart disease, and infectious diseases. FDA approved drugs such as immunotherapeutic proteins, single-stranded DNA, small molecule drugs such as doxorubicin can be […]
Hyaluronic acid (HA) is involved in various biologic processes such as hydration, nutrient exchange, and cell differentiation and motility. Hyaluronic acid is a major component of the skin’s extracellular matrix. Topical Delivery of Hyaluronic AcidFrequently, due to its high molecular weight and charge, HA is a difficult molecule to deliver into the skin. A joint […]
Creative PEGWorks has collected hundreds of papers published in peer-reviewed journals citing the use of PEG derivatives for PEGylation of proteins, enzymes, antibodies, peptides, biologic, nucleic acids, nanoparticles, chips, surfaces, dendrimers, hydrogels, liposomes and micelles. These papers describe detailed procedures and chemistry reaction conditions as well as experiment characterization data for the use of PEGylation […]
A research group from the Republic of Korea developed poly(ethylene glycol)-conjugated hyaluronic acid nanoparticles (PEG-HANPs) with high tumor targetability. Doxorubicin (DOX) was chosen as the model anticancer drug and was effectively encapsulated into the mineralized nanoparticles. How PEGylated Drugs Impact Cancer Research“The most effective antitumor efficacy was observed for DOX-loaded PEG-HANPs. Overall, these results suggest […]
Creative PEGWorks developed a series of amphiphilic, surfactant-like PEG derivatives and they are now available for purchase online. PEG surfactants and pegylated lipids can be used for drug delivery and formulation, to enhance drug solubility, improve bioavailability and pharmacokinetics, enable targeting cell receptors, and amplify imaging signals. PEGs in Drug Delivery & FormulationSuccessful examples of […]
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