Latest products update, new products introduction, PEG and biopolymer breakthrough research and products news.
Regulatory updates on PEGylated drugs and biopolymer medical devices.
Natural Polysaccharides One of the most exciting fields of medicine today is not on the direct patient contact side of the aisle. The research that is being done using Natural polysaccharides and carbohydrates is bound to change the world of modern medicine for good. Many of the changes that will erupt have yet to be […]
What Is a Biopolymer? A biopolymer is a polymer produced by living organisms, such as DNA and proteins, that are made of repetitive units called monomers. Where Are Biopolymers Found? Biopolymers are essential to every living organism. For example, cellulose, a biopolymer, is the most common organic compound on Earth and accounts for 33% of […]
FDA has approved AstraZeneca’s Movantik for opioid-induced constipation in adults with chronic non-cancer pain. Movantik (naloxegol), an oral once-a-day treatment originally developed by Nektar Therapeutics, can decrease the constipating effects of opioids. The drug’s safety and effectiveness were established in two clinical trials. What Is PEGylated Naloxegol? Naloxegol is PEGylated naloxol, which is a peripherally-selective […]
Nanolipoprotein particles (NLPs), which are mimetics of naturally occurring high-density lipoproteins (HDLs) present in the human body have been suggested as a new delivery platform for a range of therapeutics for cancer chemotherapy, heart disease, and infectious diseases. FDA approved drugs such as immunotherapeutic proteins, single-stranded DNA, small molecule drugs such as doxorubicin can be […]
Hyaluronic acid (HA) is involved in various biologic processes such as hydration, nutrient exchange, and cell differentiation and motility. Hyaluronic acid is a major component of the skin’s extracellular matrix. Topical Delivery of Hyaluronic Acid Frequently, due to its high molecular weight and charge, HA is a difficult molecule to deliver into the skin. A […]
Creative PEGWorks has collected hundreds of papers published in peer-reviewed journals citing the use of PEG derivatives for PEGylation of proteins, enzymes, antibodies, peptides, biologic, nucleic acids, nanoparticles, chips, surfaces, dendrimers, hydrogels, liposomes and micelles. These papers describe detailed procedures and chemistry reaction conditions as well as experiment characterization data for the use of PEGylation […]
A research group from the Republic of Korea developed poly(ethylene glycol)-conjugated hyaluronic acid nanoparticles (PEG-HANPs) with high tumor targetability. Doxorubicin (DOX) was chosen as the model anticancer drug and was effectively encapsulated into the mineralized nanoparticles. How PEGylated Drugs Impact Cancer Research “The most effective antitumor efficacy was observed for DOX-loaded PEG-HANPs. Overall, these results […]
Creative PEGWorks developed a series of amphiphilic, surfactant-like PEG derivatives and they are now available for purchase online. PEG surfactants and pegylated lipids can be used for drug delivery and formulation, to enhance drug solubility, improve bioavailability and pharmacokinetics, enable targeting cell receptors, and amplify imaging signals. PEGs in Drug Delivery & Formulation Successful examples […]
Researchers from the Massachusetts General Hospital and Harvard Medical School developed the novel, “PEG-like Nanoprobes,’’ with controllable pharmacokinetics and tunable fluorescence. The “PEG-like Nanoprobes’’ nanoparticles feature a unique design where a single PEG polymer surrounds a short fluorochrome and radiometal bearing peptide, and endows the resulting nanoprobe with pharmacokinetic control (based on the molecular weight […]
Researchers from the University of Washington and the Howard Hughes Medical Institute use an innovative computational design approach coupled with in-vitro-targeted evolution to produce a potent polypeptide inhibitor that triggers apoptosis of virus-infected cancer cells, suppresses tumor growth, and extends survival in a xenograft model of EBV-positive human lymphoma. How Designer Proteins Impact Cancer Research […]
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