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FDA Approves Constipation Drug PEGylated Naloxol

FDA has approved AstraZeneca’s Movantik for opioid-induced constipation in adults with chronic non-cancer pain. Movantik (naloxegol), an oral once-a-day treatment originally developed by Nektar Therapeutics, can decrease the constipating effects of opioids. The drug’s safety and effectiveness were established in two clinical trials.

What Is PEGylated Naloxegol?

Naloxegol is PEGylated naloxol, which is a peripherally-selective opioid antagonist. It is a PEGylated small molecule drug with a circulation half-life of 6-11 hours and it is primarily excreted through the feces and urine. Its structure contains a methoxy capped heptaethylene glycol (mPEG7) conjugated to naloxol through an ether linkage.

  • Molecular formula: C33H51NO11
  • Molecular weight: 637.758

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