Surfactant-like PEG Derivatives for Drug Delivery

Creative PEGWorks developed a series of amphiphilic, surfactant-like PEG derivatives and they are now available for purchase online. PEG surfactants and pegylated lipids can be used for drug delivery and formulation, to enhance drug solubility, improve bioavailability and pharmacokinetics, enable targeting cell receptors, and amplify imaging signals.

PEGs in Drug Delivery & Formulation

Successful examples of PEG derivatives used for drug delivery include:

• Pegylated liposome (Doxil), and core-shell copolymer micelles, which are prepared by self-assembly of pegylated phospholipids and PEG copolymers (PLA-PEG, PLGA-PEG, PCL-PEG), respectively.
• PEGylated lipids and PEG phospholipids conjugates.
• Functionalized PEG lipids – maleimide, amine, biotin, thiol, azide, alkyne, acid, NHS ester, hydrazide, hydroxyl and other custom reactive groups.
• Polydispersed PEG molecular weights: 1000, 2000, 3400, 5000, 10000, 20000, and 30000; Discrete oligoPEG – tetraethylene glycol, hexaethylene glycol, octaethylene glycol, dodecaethylene glycol.
• Lipids – DSPE, DMPE, octadecyl , hexadecyl, and dodecyl, Lauric Acid, Palmitic Acid, Stearic Acid, cholesterol