Poly and Acrylamide Allow Drugs to Reach Their Target Faster Many people who experience illnesses that require huge doses of drugs often have trouble entering the bloodstream. Researchers have figured out a way to ease this process by utilizing Poly and Acrylamide. These biocompatible polymers are water soluble and have the ability to stabilize water-repelling […]
In November 2015, the Food and Drug Administration approved the use of Amgen’s pegfilgrastim (Neulasta) to increase the survival of people acutely exposed to high-dose radiation that damages the bone marrow, which will improve access to the drug in the event of a public health emergency such as a nuclear power plant accident or terrorist […]
Pegfilgrastim is a PEGylated form of the recombinant human granulocyte colony-stimulating factor analog filgrastim. It serves to stimulate the level of white blood cells. Pegfilgrastim has a human half-life of 15 to 80 hours, much longer than the parent filgrastim (3–4 hours). Pharma Companies & PEGylated Drug Development Multiple major pharma companies have been busy […]
Immune responses to therapeutic protein products may pose problems for both patient safety and product efficacy. Immunologically based adverse events, such as anaphylaxis, cytokine release syndrome, and cross-reactive neutralization of endogenous proteins mediating critical functions, have caused sponsors to terminate the development of what otherwise may have been efficacious therapeutic protein products. Potential Effects of […]
PEG reagents are commonly used to prepare stable colloidal metal nanoparticle dispersion such as gold and silver through PEG thiol chemistry among other pegylation strategies. It typically works by replacing citrate or other capping ligands. How PEGs Control Variability in Gold Nanoparticles Did you know? By controlling the ratio of PEG-SH reagents to AuNP, you […]
A new ingredient is sweeping the anti-aging beauty scene and completely revolutionizing it. Where injections once ruled the beauty industry, Hyaluronic Acid is now stepping in. How Hyaluronic Acid Works This natural ingredient helps reverse the signs of anti-aging by greatly diminishing fine lines and wrinkles. Hyaluronic acid works in the skin to absorb water, […]
How the Human Head Transplant Will Happen A human head transplant sounds like something out of a science fiction movie but soon it will become reality. Valery Spiridonov, a Russian computer scientist with Werdnig-Hoffman disease, will be undergoing surgery at the end of 2017. Surgery is expected to take 36 hours and will be done […]
Soft tissue defects are relatively common, yet currently used reconstructive treatments have varying success rates. The common treatments also have serious potential complications such as unpredictable volume loss and reabsorption. How PEGs Support Stem Cell Regeneration Human adipose-derived stem cells have great potential for use in soft tissue regeneration, especially when combined with a supportive […]
What is the Difference? Bipolymers A major defining difference between biopolymers and other polymers can be found in their structures. All polymers are made of repetitive units called monomers. Biopolymers often have a well-defined structure, though this is not a defining characteristic. The exact chemical composition and the sequence in which these units are arranged […]
FDA-Approved PEGylated Drugs & Their Uses 1. Plegridy (Biogen 2014) PEGylated Interferon Beta-1a for the treatment of patients with relapsing forms of multiple sclerosis. 2. Naloxegol (Movantik) (AstraZeneca 2014) PEGylated naloxol for the treatment of opioid-induced constipation in adults patients with chronic non-cancer pain. 3. Pegnesatide (Omontys) (Takeda Pharmaceuticals, 2012) To treat anemia associated with […]
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