PEG reagents are commonly used to prepare stable colloidal metal nanoparticle dispersion such as gold and silver through PEG thiol chemistry among other pegylation strategies. It typically works by replacing citrate or other capping ligands. How PEGs Control Variability in Gold Nanoparticles Did you know? By controlling the ratio of PEG-SH reagents to AuNP, you […]
A new ingredient is sweeping the anti-aging beauty scene and completely revolutionizing it. Where injections once ruled the beauty industry, Hyaluronic Acid is now stepping in. How Hyaluronic Acid Works This natural ingredient helps reverse the signs of anti-aging by greatly diminishing fine lines and wrinkles. Hyaluronic acid works in the skin to absorb water, […]
How the Human Head Transplant Will Happen A human head transplant sounds like something out of a science fiction movie but soon it will become reality. Valery Spiridonov, a Russian computer scientist with Werdnig-Hoffman disease, will be undergoing surgery at the end of 2017. Surgery is expected to take 36 hours and will be done […]
Soft tissue defects are relatively common, yet currently used reconstructive treatments have varying success rates. The common treatments also have serious potential complications such as unpredictable volume loss and reabsorption. How PEGs Support Stem Cell Regeneration Human adipose-derived stem cells have great potential for use in soft tissue regeneration, especially when combined with a supportive […]
What is the Difference? Bipolymers A major defining difference between biopolymers and other polymers can be found in their structures. All polymers are made of repetitive units called monomers. Biopolymers often have a well-defined structure, though this is not a defining characteristic. The exact chemical composition and the sequence in which these units are arranged […]
FDA-Approved PEGylated Drugs & Their Uses 1. Plegridy (Biogen 2014) PEGylated Interferon Beta-1a for the treatment of patients with relapsing forms of multiple sclerosis. 2. Naloxegol (Movantik) (AstraZeneca 2014) PEGylated naloxol for the treatment of opioid-induced constipation in adults patients with chronic non-cancer pain. 3. Pegnesatide (Omontys) (Takeda Pharmaceuticals, 2012) To treat anemia associated with […]
Hydrogels have gained significant attention as ideal delivery vehicles for protein drugs. However, the use of hydrogels for protein delivery has been restricted because their porous structures inevitably cause a premature leakage of encapsulated proteins. PEG Hydrogels in Biomedical Applications A simple yet effective approach was recently reported to regulate the protein release kinetics of […]
References for Hyaluronic Acid and Heparin Drug Delivery System 1. Hyaluronic Acid 2. Hyaluronate Fluorescein or FITC-labeled hyaluronan 3. Hyaluronate Rhodamine 4. Heparin Rhodamine
The Lai lab at UNC Chapel Hill published an article in Molecular Pharmaceiuticals – Evading Immune Cell Uptake and Clearance Requires PEG Grafting at Densities Substantially Exceeding the Minimum for Brush Conformation. Mol. Pharmaceutics, 2014, 11 (4), pp 1250–1258, DOI: 10.1021/mp400703d. Exploration in PEG Grafting This paper critically pointed out: Coating nanoparticles with polyethylene glycol […]
PEG Therapy Since PEG molecules bind to amino acids to target proteins, they are now being used in the Rheumatology field. For patients with Rheumatoid Arthritis who do not respond to standard treatment, the use of TNF-a inhibitors have been used as an alternative treatment. Positive signs with using this alternative treatment with a reduction […]
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