Maleimide PEG

PEG maleimides can be conjugated to proteins or peptides that have exposed cysteine residues. The maleimide group reacts specifically with the thiol group of cysteine via a Michael addition reaction, forming a stable thioether bond. This modification can be used to introduce PEG chains onto proteins, altering their solubility, stability, or immunogenicity.

PEG maleimides are employed in the design of drug delivery systems. By conjugating PEG chains to drugs or drug carriers, such as liposomes or nanoparticles, researchers can modify their pharmacokinetics, improve their circulation time in the body, reduce immunogenicity, and enhance their targeting to specific tissues or cells.

PEG maleimides can be utilized to crosslink PEG-based hydrogels. Hydrogels are three-dimensional networks of hydrophilic polymers capable of absorbing large amounts of water. By introducing PEG maleimide crosslinkers, researchers can control the mechanical properties, degradation rate, and bioactivity of hydrogels, making them suitable for various biomedical applications such as tissue engineering, drug delivery, and regenerative medicine.

PEG maleimides can be used to modify surfaces of materials or biomaterials. By immobilizing PEG chains onto surfaces via thiol-maleimide conjugation, researchers can create non-fouling surfaces that resist protein adsorption and cell adhesion. This property is valuable in applications such as biosensors, implantable medical devices, and cell culture substrates.

Our Maleimide PEG products are synthesized using cutting-edge techniques and the highest quality materials, ensuring superior purity, consistency, and reproducibility in every batch. With stringent quality control measures in place, you can trust in the reliability and accuracy of our products for your critical experiments and applications.

Harness the power of site-specific protein modification with unparalleled precision. Our Maleimide PEG derivatives facilitate seamless conjugation to thiol-containing biomolecules, enabling you to engineer customized bioconjugates with enhanced stability, solubility, and functionality. Whether you’re exploring targeted drug delivery, biomaterials design, or diagnostic assays, our products provide the foundation for transformative discoveries.

Tailored to meet the diverse needs of your projects, our Maleimide PEG portfolio offers a range of molecular weights, linker lengths, and functional groups. From simple PEGylation to complex hydrogel crosslinking, unleash your creativity and explore a multitude of applications with confidence. Need a custom solution? Our team of experts is dedicated to collaborating with you to design bespoke formulations aligned with your specific requirements.

At Creative PEGWorks, we prioritize your success. Our knowledgeable team of scientists and engineers is committed to providing unparalleled technical support and guidance every step of the way. Whether you have questions about product selection, protocol optimization, or troubleshooting challenges, we are here to assist you in overcoming obstacles and achieving your research goals.