Catalog No. : PSB-4072
Product Name : 4-Arm PEG-DBCO, MW 20k
Description :

The dibenzocyclooctyne group (DBCO) reacts with molecules containing azide groups (–N3) in a Copper-free Click Chemistry. DBCO has very high reaction selectivity toward azide, enabling its use in modifying biomolecules including peptide, protein, enzyme, live cells, whole organisms etc. At physiological temperature and pH ranges, the DBCO group does not react with amine or hydroxyl, and DBCO also reacts with the azide group much faster than with free thiol groups. DBCO is also known as ADIBO (= Azadibenzocyclooctyne) or DIBAC (= Dibenzoazacyclooctyne).

References:

1. Main-Chain Liquid Crystalline Hydrogels that Support 3D Stem Cell Culture, Biomacromolecules 2020, doi: 10.1021/acs.biomac.0c00316

2. The Design of Vaccines Based on the Shielding of Antigenic Site Ø of a Respiratory Syncytial Virus Fusion Protein Immunogen, Adv. Healthcare Mater, 2020, doi: 10.1002/adhm.202000714

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