Catalog No. : PHB-948
Product Name : MAL-PEG-OH, MW 3.4k
Description :

MAL-PEG-OH is a linear heterobifunctional PEG reagent with a maleimide and a hydroxyl group. It is a useful crosslinking reagent with a PEG spacer. Maleimide reacts with thiol, SH, sulfhydryl or mercapto, and hydroxyl can react with carboxylic acid. MAL-PEG-OH can also be used to synthesize PEGylated block copolymer such as PLA-PEG (poly-L-lactic acid-co-polyethylene glycol) and PCL-PEG (polycaprolactone-co-polyethylene glycol) through hydroxyl initiated polymerization with lactide or caprolactone. Maleimide contains a reactive C=C double bond and is light or oxygen sensitive.

References: 1. αvβ3 Integrin-targeted reduction-sensitive micellar mertansine prodrug: Superb drug loading, enhanced stability, and effective inhibition of melanoma growth in vivo, Journal of Controlled Release, 2017, Pages 176-186, Text.

2. Biodegradable Fluorescent Nanoparticles for Endoscopic Detection of Colorectal Carcinogenesis, Advanced Functional Materials, 2019, Text.

3. Microwave-assisted synthesis of self-assembling bi-functionalizable amphiphilic diblock copolymers, Journal of Drug Delivery Science and Technology, 2020, Text.

Click here to view an expanded list of hundreds of publications citing Creative PEGWorks products.

Structure :
Price :
Copyright © 2021 Creative PEGWorks. All rights reserved.