Catalog No. : PHB-1970
Product Name : ACA-PEG-SCM, MW 2k
Description :

Acrylamide-PEG-SCM is a linear heterobifunctional PEG reagent with an Acrylamide (ACA) and an activated NHS ester. The C=C double bond is connected to PEG via an amide bond. It is a useful crosslinking reagent with a PEG spacer. Acrylamide can polymerize with UV light or radical initiator, and SCM is one type of NHS esters, often called succinimidyl carboxyl methyl (SCM) ester. SCM is very reactive with primary amine to form a stable amide bond. Acrylamide-PEG-SCM may be used to introduce an amine reactive functional group in crosslinked PEG hydrogel.

References: 1. Protein Conjugation (Amine PEGylation) to PEG Hydrogel - Bioartificial matrices for therapeutic vascularization, Proc Natl Acad Sci USA. 2010; 107(8): 3323–3328, Text.

2. Crosslinking Proteins to PEG Hydrogels - Injectable laminin-functionalized hydrogel for nucleus pulposus regeneration, Biomaterials, 2013 (34): 7381-7388, Text.

3. Crosslinking Proteins to PEG Hydrogels - Photocrosslinkable laminin-functionalized polyethylene glycol hydrogel for intervertebral disc regeneration, Acta Biomaterialia 10 (2014) 1102–1111, Text.

4. Bioartificial matrices for therapeutic vascularization. Proceedings of the National Academy of Sciences 107.8 (2010): 3323-3328. Text.

5. PEG-PCL Hydrogel and Conjugation of Proteins - Shape Memory RGD-Containing Networks: Synthesis, Characterization, and Application in Cell Culture, Macromol. Symp. 2011, 309/310, 162–172,Text.

6. Preparation of Protein–Polymer Conjugates: Copolymerisation by RAFT, 2020, DOI: 10.1071/CH19514

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