Catalog No. : PLS-9924
Product Name : DSPE-PEG-NH2, MW 5k
Description :

DSPE-PEG-NH2 is a linear heterobifunctional PEGylation reagent with a DSPE phospholipid and an amine. It is a useful self-assembling reagent to prepare grafted or PEGylated liposome or micelle while also providing an amine group for bioconjugation. It is often used in targeted drug delivery with the lipid bilayer to improve drug solubility, the PEG to provide stealth property, extend circulation half-life and reduce non-specific protein binding or cell adhesion, and the amine group to bioconjugate targeting molecules including antibody, aptamer, protein, and peptide.

References:

1. Radiolabeled, antibody-conjugated manganese oxide nanoparticles for tumor vasculature targeted positron emission tomography and magnetic resonance imaging. ACS applied materials & interfaces. 2017 Oct 24;9(44):38304-12. Text.

2. Magnetic Targeting of Nanotheranostics Enhances Cerenkov Radiation-Induced Photodynamic Therapy. Journal of the American Chemical Society. 2018 Oct 18. Text.

3. GMBP1-conjugated manganese oxide nanoplates for in vivo monitoring of gastric cancer MDR using magnetic resonance imaging, RSC Adv., 2020, 10, 13687-13695, Text.

4. Efficient Lymph Node-Targeted Delivery of Personalized Cancer Vaccines with Reactive Oxygen Species-Inducing Reduced Graphene Oxide Nanosheets, ACS Nano, 2020, DOI: 10.1021/acsnano.0c05062

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