DSPE-PEG-FITC is a linear heterobifunctional PEGylation reagent with a DSPE
phospholipid and a fluorescein FITC dye. Fluorescein often called FITC is a commonly used fluorescent tracer in biology for staining cells, tissues, biomarkers or nanoparticles. It has peak absorption or excitation at 494 nm and maximum emission at 521 nm.Â It is a useful self-assembling reagent to
prepare grafted or PEGylated liposome or micelle while also providing fluorescent dye label/tag. It is often used in
targeted drug delivery with the lipid bilayer to improve drug
solubility, the PEG to provide stealth property, extend circulation
half-life and reduce non-specific protein binding or cell adhesion, and
the biotin group to non-covalently bind to targeting molecules including
antibody, aptamer, protein, and peptide.
1. Noninvasive ultrasound molecular imaging of the effect of statins on
endothelial inflammatory phenotype in early atherosclerosis. PloS one
8.3 (2013): e58761 Text.
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