OPSS-PEG-OPSS is a bifunctional PEGylation crosslinker reagent. OPSS stands for ortho-pyridyl disulfide or ortho pyridyldithio, or PDP, pyridyl dithio propionate. OPSS reacts with thiol, SH, sulfhydryl or mercapto to form an oxidation, reduction reversible PEG disulfide bond. Under certain conditions, OPSS generates free thiols in aqueous solution for direct PEGylation of novel metal such as gold and silver nanoparticles.
Molecular weight: MW of PEG was measured by MALDI-MS or GPC. PDI (polydispersity index) of our linear PEG is 1.02-1.05 with very narrow MW distribution. The number of repeating ethylene oxide units (CH2CH2O) or the degree of polymerization is calculated dividing the PEG MW by 44 (44 is the molecular mass of one repeating unit).
Solubility: Soluble in water and aqueous buffer, chloroform, methylene chloride, DMF, DMSO, and less soluble in alcohol, toluene. Not soluble in ether.
Density: PEG density is approximately 1.125 g/mL
Physical form: PEG products generally appear as white or off-white powder, and for very low MW linear PEG such as MW 1k or less, it may appear as wax-like, semi-solid material due to the low MW and the type of functional groups.
Storage condition: PEG product shall be stored in the original form as received in a freezer at -20C or lower for long term storage. Stock solution of PEG reagents that do not contain oxygen or moisture sensitive functional groups may be temporarily stored in a refrigerator or ambient temperature for multiple days. Stock solution should avoid repeated freeze-and-thaw cycles. See Documents section for detailed storage and handling conditions.
1. Self-Assembled Stimuli-Responsive Polyrotaxane Coreâ€“Shell Particles. Biomacromolecules 15.1 (2013): 53-59. Text
2. On-Demand Cascade Release of Hydrophobic Chemotherapeutics from a Multicomponent Hydrogel System. ACS Biomaterials Science & Engineering4.5 (2018): 1696-1707. Text.
3. Polyrotaxane Nanocarriers Can Deliver CRISPR/Cas9 Plasmid to Dystrophic Muscle Cells to Successfully Edit the DMD Gene, Advanced Therapeutics, 2019, doi: 10.1002/adtp.201900061
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