mPEG-Pyrene is a PEGylated pyrene derivative for surface functionalization of carbon materials. Include carbon nanotube (CNT), graphene, graphene oxide (GO), reduced graphene oxide (rGO). Pyrene conjugation to PEG is through a very stable amide bond.
The strong pi-pi stacking between pyrene and the aromatic rings on single wall and multi-walled carbon nanotubes and other graphitic surfaces is close to covalent bonding strength. The interaction is stronger when the carbon surface curvature matches that of pyrene.
It is a very simple process to coat CNT with PEG through pyrene interactions. It is as simple as dispersing CNT with the PEG-pyrene reagents in organic solvents or aqueous solutions.
The same PEGylated pyrene procedure also works for graphene or any carbon particle surfaces with curvatures that fit well with the pyrene structure.
Custom synthesis of functional Pyrene-PEG derivatives is available. The list includes Pyrene-PEG-Pyrene, X-PEG-Pyrene where X is Amine, Acrylate, Biotin, FITC, Rhodamine, Maleimide.
Molecular weight: MW of PEG was measured by MALDI-MS or GPC. PDI (polydispersity index) of our linear PEG is 1.02-1.05 with very narrow MW distribution. The number of repeating ethylene oxide units (CH2CH2O) or the degree of polymerization is calculated dividing the PEG MW by 44 (44 is the molecular mass of one repeating unit).
Solubility: Soluble in water and aqueous buffer, chloroform, methylene chloride, DMF, DMSO, and less soluble in alcohol, toluene. Not soluble in ether.
Density: PEG density is approximately 1.125 g/mL
Physical form: PEG products generally appear as white or off-white powder, and for very low MW linear PEG such as MW 1k or less, it may appear as wax-like, semi-solid material due to the low MW and the type of functional groups.
Storage condition: PEG product shall be stored in the original form as received in a freezer at -20C or lower for long term storage. Stock solution of PEG reagents that do not contain oxygen or moisture sensitive functional groups may be temporarily stored in a refrigerator or ambient temperature for multiple days. Stock solution should avoid repeated freeze-and-thaw cycles. See Documents section for detailed storage and handling conditions.
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2. Charles M Lieber et al, Specific detection of biomolecules in physiological solutions using graphene transistor biosensors, Proc. Natl. Acad. Sci. USA, DOI 10.1073/pnas.1625010114, 2016,Text,PDF.
3. Effect of hydrophobic interaction in the poly(methacrylic acid)/pyrene end-labeled poly(ethylene glycol) complex,Macromolecules,1987, 20 (8), pp 1839-1847, Text
4. Non-covalent and reversible functionalization of carbon nanotubes, Beilstein J. Nanotechnol.2014,Â 5, 1675-1690, Text.
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