Description
mPEG-DSPE is a linear PEG phospholipid with saturated C18 stearoyl fatty acid (octadecanoic acid). DSPE full name is 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine. DSPE CAS number is 1069-79-0. Other PEG lipid reagents including arachidic, palmitic, myristic, lauric, and capric acid, and unsaturated fatty acids are available through our custom synthesis service. mPEG-phospholipid is an amphiphilic PEG or surfactant PEG. mPEG-phospholipid is useful to form stealth liposome or micelle for targeted drug delivery and drug solubility enhancement.
Properties
Molecular weight: MW of PEG was measured by MALDI-MS or GPC. PDI (polydispersity index) of our linear PEG is 1.02-1.05 with very narrow MW distribution. The number of repeating ethylene oxide units (CH2CH2O) or the degree of polymerization is calculated dividing the PEG MW by 44 (44 is the molecular mass of one repeating unit).
Solubility: Soluble in water and aqueous buffer, chloroform, methylene chloride, DMF, DMSO, and less soluble in alcohol, toluene. Not soluble in ether.
Density: PEG density is approximately 1.125 g/mL
Physical form: PEG products generally appear as white or off-white powder, and for very low MW linear PEG such as MW 1k or less, it may appear as wax-like, semi-solid material due to the low MW and the type of functional groups.
Storage condition: PEG product shall be stored in the original form as received in a freezer at -20C or lower for long term storage. Stock solution of PEG reagents that do not contain oxygen or moisture sensitive functional groups may be temporarily stored in a refrigerator or ambient temperature for multiple days. Stock solution should avoid repeated freeze-and-thaw cycles. See Documents section for detailed storage and handling conditions.
References
1. Using 915 nm Laser Excited Tm³+/Er³+/Ho³+-Doped NaYbF4 Upconversion Nanoparticles for in Vitro and Deeper in Vivo Bioimaging without Overheating Irradiation, ACS Nano, 2011, 5 (5), pp 3744-3757, Text.
2. Green-synthesized near-infrared PbS quantum dots with silica-PEG dual-layer coating: ultrastable and biocompatible optical probes for in vivo animal imaging, 2012 Nanotechnology 23 245701, Text.
3. Biocompatible and Photostable AIE Dots with Red Emission for In Vivo Two-Photon Bioimaging. Sci. Rep. 2014, 4, 4279, Text.
4. Optimization of Optical Excitation of Upconversion Nanoparticles for Rapid Microscopy and Deeper Tissue Imaging with Higher Quantum Yield. Theranostics 2013, 3 (5):306-316, Text.
5. Cisplatin-alginate conjugate liposomes for targeted delivery to EGFR-positive ovarian cancer cells. Biomaterials 35.14 (2014): 4297-4309. Text.
6. Optimizing Sensitivity of Ultrasound Contrast-Enhanced Super-Resolution Imaging by Tailoring Size Distribution of Microbubble Contrast Agent, Ultrasound in Medicine & Biology, 10, 2017, 2488-249, Text.
7. 3-D Ultrasound Localization Microscopy for Identifying Microvascular Morphology Features of Tumor Angiogenesis at a Resolution Beyond the Diffraction Limit of Conventional Ultrasound, Theranostics 7(1):196-204, 2017, Text.
8. Toxicity assessment and long-term three-photon fluorescence imaging of bright aggregation-induced emission nanodots in zebrafish, Nano Research, 2016, 9(7), 1921-1933, Text.
9. Zapped assembly of polymeric (ZAP) nanoparticles for anti-cancer drug delivery, Nanoscale, 2019,11, 1847-1855, Text.
10. Optimization, stabilization, and characterization of amphotericin B loaded nanostructured lipid carriers for ocular drug delivery, 2019, Text.
11. Effect of Acoustic Parameters and Microbubble Concentration on the Likelihood of Encapsulated Microbubble Coalescence, Ultrasound in Medicine & Biology, 2021, 2980-2989, Text.
12. Development of theranostic dual-layered Au-liposome for effective tumor targeting and photothermal therapy, Journal of Nanobiotechnology volume 19, Article: 262 (2021) , Text.
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