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mPEG-Carbonylacrylic, MW 1k

mPEG-Carbonylacrylic, MW 1k

Catalog No: PSB-2601
Product Name: mPEG-Carbonylacrylic, MW 1k
In Stock: Yes
SKUProduct Name
PSB-2601-500mg
mPEG-Carbonylacrylic, MW 1k - 500mg
$350.00
-
+
PSB-2601-1g
mPEG-Carbonylacrylic, MW 1k - 1g
$550.00
-
+
PSB-2601-5g
mPEG-Carbonylacrylic, MW 1k - 5g
$1,450.00
-
+
Total: $0.00
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Description

mPEG-Carbonylacrylic (mPEG-CA) are for chemoselective cysteine bioconjugation. Carbonylacrylic PEG reagents undergo rapid thiol Michael-addition under biocompatible conditions in stoichiometric amounts. Importantly, the conjugates formed between Carbonylacrylic PEG and thiol/cysteine-containing molecules are resistant to degradation in physiological conditions. The typical maleimide-thiol reaction results in thiosuccinimide formation which is reversible, with PEG-maleimide elimination occurring slowly under biologically relevant conditions. The reversed reaction leads to the breakage of the maleimide-thiol linkage and the loss of PEG from the thiol/cysteine-containing molecules. If the maleimide-thiol chemistry does not work for your application, you may consider Carbonylacrylic PEG reagents as an improved alternative to PEG-maleimide.

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