Description
mPEG-Amine is a linear methoxy PEG reagent with a reactive primary amino or NH2 group. Amine can rapidly react with activated carboxyl acid such as NHS ester to form stable amide bonds. Amine can also react with carbonyl such as ketone and aldehyde. mPEG-Amine with MW at 1k or higher appears as white powder and at lower MW (e.g. 550 and 350) appears as white or off-white semi-solid or wax-like due to their low melting/freezing temperature range (e.g. mPEG MW 550 at 15-25 Celsius). mPEG-Amine is in its free amine form. If you require the salt form (HCl or TFA), please contact us.
Properties
Molecular weight: MW of PEG was measured by MALDI-MS or GPC. PDI (polydispersity index) of our linear PEG is 1.02-1.05 with very narrow MW distribution. The number of repeating ethylene oxide units (CH2CH2O) or the degree of polymerization is calculated dividing the PEG MW by 44 (44 is the molecular mass of one repeating unit).
Solubility: Soluble in water and aqueous buffer, chloroform, methylene chloride, DMF, DMSO, and less soluble in alcohol, toluene. Not soluble in ether.
Density: PEG density is approximately 1.125 g/mL
Physical form: PEG products generally appear as white or off-white powder, and for very low MW linear PEG such as MW 1k or less, it may appear as wax-like, semi-solid material due to the low MW and the type of functional groups.
Storage condition: PEG product shall be stored in the original form as received in a freezer at -20C or lower for long term storage. Stock solution of PEG reagents that do not contain oxygen or moisture sensitive functional groups may be temporarily stored in a refrigerator or ambient temperature for multiple days. Stock solution should avoid repeated freeze-and-thaw cycles. See Documents section for detailed storage and handling conditions.
References
1. Charles M Lieber et al, Specific detection of biomolecules in physiological solutions using graphene transistor biosensors, Proc. Natl. Acad. Sci. USA, DOI 10.1073/pnas.1625010114, 2016, Text.
2. Design and demonstration of a small-animal upconversion imager, Opt Express. 2008 December 22; 16(26): 21731-21737, Text.
3. Fluorescence Single Particle Tracking for the Characterization of Submicron Protein Aggregates in Biological Fluids and Complex Formulations, Pharm Res (2011) 28:1112-1120, Text.
4. Characterization of hydrogel microstructure using laser tweezers particle tracking and confocal reflection imaging, J Phys Condens Matter. 2010; 22(19): 194121, Text.
5. Ex vivo characterization of particle transport in mucus secretions coating freshly excised mucosal tissues, Mol Pharm. 2013 June 3; 10(6): 2176-2182, Text.
6. Nanoparticle diffusion in respiratory mucus from humans without lung disease, Biomaterials. 2013 April ; 34(13): 3439-3446, Text.
7. Convection enhanced delivery of cisplatin-loaded brain penetrating nanoparticles cures malignant glioma in rats, J. Controlled Release, 2017, 263, 112-119, Text.
8. MR image-guided delivery of cisplatin-loaded brain-penetrating nanoparticles to invasive glioma with focused ultrasound, Journal of Controlled Release, Volume 263, 10 October 2017, 120-131. Text.
9. Blood component ridable and CD44 receptor targetable nanoparticles based on a maleimide-functionalized chondroitin sulfate derivative, Carbohydrate Polymers, 2019, 115568, Text.
10. Positron emission tomography imaging of novel AAV capsids maps rapid brain accumulation, Nature Communications, 2020, Text.
11. Generating an in vitro gut model with physiologically relevant biophysical mucus properties, 2022, Text.
12. Polypseudorotaxane and polydopamine linkage-based hyaluronic acid hydrogel network with a single syringe injection for sustained drug delivery, Carbohydrate Polymers 2021, 118104, Text.
13. Superswelling Microneedle Arrays for Dermal Interstitial Fluid (Prote)Omics, Advanced Functional Materials, 2021, 2106061, Text.
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