mPEG-Acrylamide is a linear monofunctional PEG reagent with an acrylamide (ACA) group. ACA is useful for radical initiator or UV light induced polymerization. It is often used to prepare PEG hydrogel. Instead of an ester linkage in mPEG-Acrylate, mPEG-Acrylamide has a more stable amide linker. mPEG-Methacrylamide is also available to provide as an alternative to acrylamide.
Molecular weight: MW of PEG was measured by MALDI-MS or GPC. PDI (polydispersity index) of our linear PEG is 1.02-1.05 with very narrow MW distribution. The number of repeating ethylene oxide units (CH2CH2O) or the degree of polymerization is calculated dividing the PEG MW by 44 (44 is the molecular mass of one repeating unit).
Solubility: Soluble in water and aqueous buffer, chloroform, methylene chloride, DMF, DMSO, and less soluble in alcohol, toluene. Not soluble in ether.
Density: PEG density is approximately 1.125 g/mL
Physical form: PEG products generally appear as white or off-white powder, and for very low MW linear PEG such as MW 1k or less, it may appear as wax-like, semi-solid material due to the low MW and the type of functional groups.
Storage condition: PEG product shall be stored in the original form as received in a freezer at -20C or lower for long term storage. Stock solution of PEG reagents that do not contain oxygen or moisture sensitive functional groups may be temporarily stored in a refrigerator or ambient temperature for multiple days. Stock solution should avoid repeated freeze-and-thaw cycles. See Documents section for detailed storage and handling conditions.
1. Polymeric plerixafor: effect of PEGylation on CXCR4 antagonism, cancer cell invasion, and DNA transfection. Pharmaceutical research 31.12 (2014): 3538-3548. Text.
2. Polyplex-mediated inhibition of chemokine receptor CXCR4 and chromatin-remodeling enzyme NCOA3 impedes pancreatic cancer progression and metastasis, Biomaterials Volume 101, 2016, 108-120, Text.
3. Polycation fluorination improves intraperitoneal siRNA delivery in metastatic pancreatic cancer, Journal of Controlled Release 333 (2021) 139–150, Text.
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