Description
Methacrylate-PEG-Methacrylate is a linear bifunctional crosslinking PEG reagent with two Methacrylate( MAc ) groups. Methacrylate is for radical initiator polymerization or UV light sensitive photopolymerization. Methacrylate-PEG-Methacrylate upon polymerization forms crosslinked polymer network and PEG hydrogel. PEG-Methacrylate is an ester of PEG-OH with methacrylic acid. The amide version methacrylamide-PEG methacrylamide is available via custom synthesis. 4-Methoxyphenol or MeHQ at ~200 ppm is present in the lyophilized powder as inhibitors.
Properties
Molecular weight: MW of PEG was measured by MALDI-MS or GPC. PDI (polydispersity index) of our linear PEG is 1.02-1.05 with very narrow MW distribution. The number of repeating ethylene oxide units (CH2CH2O) or the degree of polymerization is calculated dividing the PEG MW by 44 (44 is the molecular mass of one repeating unit).
Solubility: Soluble in water and aqueous buffer, chloroform, methylene chloride, DMF, DMSO, and less soluble in alcohol, toluene. Not soluble in ether.
Density: PEG density is approximately 1.125 g/mL
Physical form: PEG products generally appear as white or off-white powder, and for very low MW linear PEG such as MW 1k or less, it may appear as wax-like, semi-solid material due to the low MW and the type of functional groups.
Storage condition: PEG product shall be stored in the original form as received in a freezer at -20C or lower for long term storage. Stock solution of PEG reagents that do not contain oxygen or moisture sensitive functional groups may be temporarily stored in a refrigerator or ambient temperature for multiple days. Stock solution should avoid repeated freeze-and-thaw cycles. See Documents section for detailed storage and handling conditions.
References
1. Thiol PEGylation of siRNA – Methods and Compositions for Improved Therapeutic Effects with siRNA, Patent US20080311040 A1, Text.
2. PEG Hydrogel- Bioartificial matrices for therapeutic vascularization, Proc Natl Acad Sci USA. 2010; 107(8): 3323-3328, Text.
3. PEG Hydrogel – Reductively Responsive siRNA-Conjugated Hydrogel Nanoparticles for Gene Silencing, J. Am. Chem. Soc., 2012, 134 (17), pp 7423-7430, Text.
4. Photocrosslinkable laminin-functionalized polyethylene glycol hydrogel for intervertebral disc regeneration, Acta Biomaterialia 10 (2014) 1102-1111,Text.
5. Hydrogel network design using multifunctional macromers to coordinate tissue maturation in ovarian follicle culture. Biomaterials 32.10 (2011): 2524-2531, Text
6. Multiplexed Dosing Assays by Digitally Definable Hydrogel Volumes. Adv. Healthcare Mater.,2016, 5: 244-254. Text
7. Microfluidic fabrication of bioactive microgels for rapid formation and enhanced differentiation of stem cell spheroids. Acta Biomater. 2016 Apr 1;34:125-132. Text
8. Microstructural alterations of sputum in cystic fibrosis lung disease, JCI Insight, 2016;1(18):e88198, Text.
9. Poly(ethylene glycol) Hydrogel Crosslinking Chemistries Identified via Atmospheric Solids Analysis Probe Mass Spectrometry, Macromolecules, 2021, 54, 17
10. HA-Thiol/PEG-Methacrylate: In situ forming biomaterials as muscle void fillers for the provisional treatment of volumetric muscle loss injuries, Materials Today Bio, Volume 22, October 2023, 100781, Text.
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