Description
MAL-PEG-SCM is a linear heterobifunctional PEG reagent with a maleimide and a succinimidyl NHS ester group. It is a useful crosslinking reagent with a PEG spacer. Maleimide reacts with thiol, SH, sulfhydryl or mercapto. SCM stands for succinimidyl carboxyl methyl ester and react with primary amine. Maleimide contains a reactive C=C double bond and is light or oxygen sensitive.
Properties
Molecular weight: MW of PEG was measured by MALDI-MS or GPC. PDI (polydispersity index) of our linear PEG is 1.02-1.05 with very narrow MW distribution. The number of repeating ethylene oxide units (CH2CH2O) or the degree of polymerization is calculated dividing the PEG MW by 44 (44 is the molecular mass of one repeating unit).
Solubility: Soluble in water and aqueous buffer, chloroform, methylene chloride, DMF, DMSO, and less soluble in alcohol, toluene. Not soluble in ether.
Density: PEG density is approximately 1.125 g/mL
Physical form: PEG products generally appear as white or off-white powder, and for very low MW linear PEG such as MW 1k or less, it may appear as wax-like, semi-solid material due to the low MW and the type of functional groups.
Storage condition: PEG product shall be stored in the original form as received in a freezer at -20C or lower for long term storage. Stock solution of PEG reagents that do not contain oxygen or moisture sensitive functional groups may be temporarily stored in a refrigerator or ambient temperature for multiple days. Stock solution should avoid repeated freeze-and-thaw cycles. See Documents section for detailed storage and handling conditions.
References
1. Structure and Biosynthesis of Two Exopolysaccharides Produced by Lactobacillus johnsonii FI9785, J. Biol. Chem. 2013, 288:31938-31951, Text.
2. Cancer-Targeted Optical Imaging with Fluorescent Zinc Oxide Nanowires, Nano Lett. 2011; 11(9): 3744-3750, Text.
3. Evolution of zinc oxide nanostructures through kinetics control, J. Mater. Chem., 2011, 21, 9000-9008, Text.
4. Design of a Modular Tetrameric Scaffold for the Synthesis of Membrane-Localized d-Peptide Inhibitors of HIV-1 Entry, Bioconjugate Chem., 2012, 23 (6), 1252-1258, Text.
5. Methylene blue covalently loaded polyacrylamide nanoparticles for enhanced tumor-targeted photodynamic therapy, Photochem. Photobiol. Sci., 2011, 10, 832-841, Text.
6. Lactobacillus reuteri Surface Mucus Adhesins Upregulate Inflammatory Responses Through Interactions With Innate C-Type Lectin Receptor, Front. Microbiol., 2017, 201700321. Text.
7. Molecular and Biocompatibility Characterization of Red Blood Cell Membrane Targeted and Cell-Penetrating-Peptide-Modified Polymeric Nanoparticles, Mol. Pharmaceutics, 2017, 14 (7), 2224-223, Text.
8. Use of Atomic Force Microscopy to Study the Multi-Modular Interaction of Bacterial Adhesins to Mucins, Int. J. Mol. Sci. 2016, 17(11), 1854; Text.
9. ZOT-derived peptide and chitosan functionalized nanocarrier for oral delivery of protein drug, Biomaterials, 2016, 160-169, Text.
10. Targeted delivery of anti-inflammatory cytokine by nanocarrier reduces atherosclerosis in Apo E-/- mice, Biomaterials, 2020, 119550, Text.
11. Erythrocytes internalize nanoparticles functionalized with low molecular weight protamine, J Nanopart Res 23, 96 (2021). Text.
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