Description
MAL-PEG-OH is a linear heterobifunctional PEG reagent with a maleimide and a hydroxyl group. It is a useful crosslinking reagent with a PEG spacer. Maleimide reacts with thiol, SH, sulfhydryl or mercapto. Hydroxyl can react with carboxylic acid. MAL-PEG-OH is useful to synthesize PEGylated block copolymer such as PLA-PEG (poly-L-lactic acid-co-polyethylene glycol) and PCL-PEG (polycaprolactone-co-polyethylene glycol) through hydroxyl initiated polymerization with lactide or caprolactone. Maleimide contains a reactive C=C double bond and is light or oxygen sensitive. MAL-PEG-OH may be also useful as a monofunctional maleimide PEG as an alternative to mPEG-Maleimide. Hydroxyl-terminated PEG has reported to have different immune responses compared to methoxy-terminated mPEG-Maleimide.
Properties
Molecular weight: MW of PEG was measured by MALDI-MS or GPC. PDI (polydispersity index) of our linear PEG is 1.02-1.05 with very narrow MW distribution. The number of repeating ethylene oxide units (CH2CH2O) or the degree of polymerization is calculated dividing the PEG MW by 44 (44 is the molecular mass of one repeating unit).
Solubility: Soluble in water and aqueous buffer, chloroform, methylene chloride, DMF, DMSO, and less soluble in alcohol, toluene. Not soluble in ether.
Density: PEG density is approximately 1.125 g/mL
Physical form: PEG products generally appear as white or off-white powder, and for very low MW linear PEG such as MW 1k or less, it may appear as wax-like, semi-solid material due to the low MW and the type of functional groups.
Storage condition: PEG product shall be stored in the original form as received in a freezer at -20C or lower for long term storage. Stock solution of PEG reagents that do not contain oxygen or moisture sensitive functional groups may be temporarily stored in a refrigerator or ambient temperature for multiple days. Stock solution should avoid repeated freeze-and-thaw cycles. See Documents section for detailed storage and handling conditions.
References
Integrin-targeted reduction-sensitive micellar mertansine prodrug: Superb drug loading, enhanced stability, and effective inhibition of melanoma growth in vivo, Journal of Controlled Release, 2017, Pages 176-186, Text.
Biodegradable Fluorescent Nanoparticles for Endoscopic Detection of Colorectal Carcinogenesis, Advanced Functional Materials, 2019,Text.
Microwave-assisted synthesis of self-assembling bi-functionalizable amphiphilic diblock copolymers, Journal of Drug Delivery Science and Technology, 2020, Text.
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