Description
HO-PEG-NH2 is a linear heterobifunctional PEG derivative with one hydroxyl and one amine group. It is a useful crosslinking reagent with a PEG spacer by sequentially reacting with amine and hydroxyl. It is also a useful monofunctional amine PEG reagent with a terminal hydroxyl group instead of methoxy as in mPEG-Amine. Hydroxyl terminated PEG has reported to have different immune responses such as antibody generation to methoxy-terminated PEG as in mPEG. Typically, it is offered as its HCl or TFA salt.
Properties
Molecular weight: MW of PEG was measured by MALDI-MS or GPC. PDI (polydispersity index) of our linear PEG is 1.02-1.05 with very narrow MW distribution. The number of repeating ethylene oxide units (CH2CH2O) or the degree of polymerization is calculated dividing the PEG MW by 44 (44 is the molecular mass of one repeating unit).
Solubility: Soluble in water and aqueous buffer, chloroform, methylene chloride, DMF, DMSO, and less soluble in alcohol, toluene. Not soluble in ether.
Density: PEG density is approximately 1.125 g/mL
Physical form: PEG products generally appear as white or off-white powder, and for very low MW linear PEG such as MW 1k or less, it may appear as wax-like, semi-solid material due to the low MW and the type of functional groups.
Storage condition: PEG product shall be stored in the original form as received in a freezer at -20C or lower for long term storage. Stock solution of PEG reagents that do not contain oxygen or moisture sensitive functional groups may be temporarily stored in a refrigerator or ambient temperature for multiple days. Stock solution should avoid repeated freeze-and-thaw cycles. See Documents section for detailed storage and handling conditions.
References
1) Multimodal doxorubicin loaded magnetic nanoparticles for VEGF targeted theranostics of breast cancer, Nanomedicine: Nanotechnology, Biology and Medicine,2018, DOI: 10.1016/j.nano.2018.04.019.
2) Immediate Hypersensitivity to Polyethylene Glycols and Polysorbates: More Common Than We Have Recognized. The Journal of Allergy and Clinical Immunology: In Practice. 2018 Dec 14. Text.
3) HSA-Coated Magnetic Nanoparticles for MRI-Guided Photodynamic Cancer Therapy, Pharmaceutics, 2018, 10, 284; doi: 10.3390/pharmaceutics10040284
4. High-resolution imaging of maltoporin LamB while quantifying the free-energy landscape and asymmetry of sugar-binding, Nano Lett. 2019, DOI: 10.1021/acs.nanolett.9b02674
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