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Carbonylacrylic-PEG-Carbonylacrylic, MW 10k

Carbonylacrylic-PEG-Carbonylacrylic, MW 10k

Catalog No: PSB-6115
Product Name: Carbonylacrylic-PEG-Carbonylacrylic, MW 10k
In Stock: Yes
SKUProduct Name
PSB-6115-500mg
Carbonylacrylic-PEG-Carbonylacrylic, MW 10k - 500mg
$350.00
-
+
PSB-6115-1g
Carbonylacrylic-PEG-Carbonylacrylic, MW 10k - 1g
$550.00
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+
PSB-6115-5g
Carbonylacrylic-PEG-Carbonylacrylic, MW 10k - 5g
$1,450.00
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+
Total: $0.00
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Description

Carbonylacrylic-PEG-Carbonylacrylic reagents are for chemoselective cysteine bioconjugation and undergo rapid thiol Michael-addition under biocompatible conditions in stoichiometric amounts. Importantly, the conjugates formed between Carbonylacrylic PEG and thiol/cysteine-containing molecules are resistant to degradation in physiological conditions. The typical PEG-maleimide-thiol reaction results in thiosuccinimide formation which is reversible, with PEG-maleimide elimination occurring slowly under biologically relevant conditions. The reversed reaction leads to the breakage of the maleimide-thiol linkage and the loss of PEG from the thiol/cysteine-containing molecules. If the maleimide-thiol chemistry does not work for your application, you may consider Carbonylacrylic PEG reagents as an improved alternative to PEG-maleimide.

Custom Synthesis (Contact Us):

mPEG-CA

4-Arm PEG-CA

8-Arm PEG-CA

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