Boc-NH-PEG-SCM, MW 3.4k

Boc-NH-PEG-SCM, MW 3.4k

Catalog No:PHB-970
Product Name:Boc-NH-PEG-SCM, MW 3.4k
In Stock: Yes
SKUProduct Name
PHB-970-100mg
Boc-NH-PEG-SCM, MW 3.4k - 100mg
$300.00
-
+
PHB-970-1g
Boc-NH-PEG-SCM, MW 3.4k - 1g
$800.00
-
+
PHB-970-5g
Boc-NH-PEG-SCM, MW 3.4k - 5g
$1,900.00
-
+
Interested in Bulk Orders? Please contact us here

Description

Boc-NH-PEG-SCM is a linear heterobifunctional PEG reagent with Boc protected amine and SCM. SCM stands for succinimidyl carboxyl methyl ester. SCM is one type of the NHS esters. It is a useful crosslinking reagent with a PEG spacer. Upon acidic deprotection, the free amine NH2 becomes reactive. Heterobifunctional PEG derivatives with other types of NHS ester is available via custom synthesis. They may include succinimidyl glutarate (SG), succinimidyl succinate (SS), glutaramide succinimidyl (GAS) or succinamide succinimidyl (SAS).

Properties

Molecular weight: MW of PEG was measured by MALDI-MS or GPC. PDI (polydispersity index) of our linear PEG is 1.02-1.05 with very narrow MW distribution. The number of repeating ethylene oxide units (CH2CH2O) or the degree of polymerization is calculated dividing the PEG MW by 44 (44 is the molecular mass of one repeating unit).

Solubility: Soluble in water and aqueous buffer, chloroform, methylene chloride, DMF, DMSO, and less soluble in alcohol, toluene. Not soluble in ether.

Density: PEG density is approximately 1.125 g/mL

Physical form: PEG products generally appear as white or off-white powder, and for very low MW linear PEG such as MW 1k or less, it may appear as wax-like, semi-solid material due to the low MW and the type of functional groups.

Storage condition: PEG product shall be stored in the original form as received in a freezer at -20C or lower for long term storage. Stock solution of PEG reagents that do not contain oxygen or moisture sensitive functional groups may be temporarily stored in a refrigerator or ambient temperature for multiple days. Stock solution should avoid repeated freeze-and-thaw cycles. See Documents section for detailed storage and handling conditions.

References

1. Guided delivery of polymer therapeutics using plasmonic photothermal therapy. Nano today 7.3 (2012): 158-167. Text

2. Somatostatin receptor-mediated tumor-targeting drug delivery using octreotide-PEG-deoxycholic acid conjugate-modified N-deoxycholic acid-O, N-hydroxyethylation chitosan micelles. Biomaterials 33.27 (2012): 6393-6407. Text

3. Somatostatin Receptor Mediated Specific Delivery of Paclitaxel Prodrugs for Efficient Cancer Therapy. Journal of pharmaceutical sciences 104.6 (2015): 2018-2028. Text

4. Well-defined Redox-sensitive Polyethene glycol-Paclitaxel Prodrug Conjugate for Tumor Specific Delivery of Paclitaxel Using Octreotide for Tumor-targeting, Mol. Pharmaceutics, 201512 (8), pp 3020-3031, Text.

Click here to view an expanded list of hundreds of publications citing Creative PEGWorks products.

Documents

 Technical Information_Linear PEG Products
 SDS of Boc-NH-PEG-SCM

Get In Touch

If you have any questions, please submit an online inquiry.

"*" indicates required fields

Your Name*
Do you wish to receive emails for new product introduction and sale promotions?
By submitting this form, you are consenting to our privacy policy.
This field is for validation purposes and should be left unchanged.