Description
Aldehyde-PEG-Aldehyde, also called ALD-PEG-ALD is a bifunctional PEG propionaldehyde. ALD-PEG-ALD is for crosslinking two substrate molecules through a PEG spacer. Aldehyde reacts with amine or N-terminal of peptide and protein to form an imine containing C=N double bond. Imine forms fa more stable C-N bond upon reduction reactions. PEG aldehyde or ketone derivatives is useful in reversible PEGylation through its reaction with hydrazine or hydrazide forming a hydrolytic acyl hydrazone linkage. PEG butyraldehyde is available through custom synthesis.
Properties
Molecular weight: MW of PEG was measured by MALDI-MS or GPC. PDI (polydispersity index) of our linear PEG is 1.02-1.05 with very narrow MW distribution. The number of repeating ethylene oxide units (CH2CH2O) or the degree of polymerization is calculated dividing the PEG MW by 44 (44 is the molecular mass of one repeating unit).
Solubility: Soluble in water and aqueous buffer, chloroform, methylene chloride, DMF, DMSO, and less soluble in alcohol, toluene. Not soluble in ether.
Density: PEG density is approximately 1.125 g/mL
Physical form: PEG products generally appear as white or off-white powder, and for very low MW linear PEG such as MW 1k or less, it may appear as wax-like, semi-solid material due to the low MW and the type of functional groups.
Storage condition: PEG product shall be stored in the original form as received in a freezer at -20C or lower for long term storage. Stock solution of PEG reagents that do not contain oxygen or moisture sensitive functional groups may be temporarily stored in a refrigerator or ambient temperature for multiple days. Stock solution should avoid repeated freeze-and-thaw cycles. See Documents section for detailed storage and handling conditions.
References
1. Effect of polyethylene glycol tether size and chemistry on the attachment of lactase to polyethylene films. Journal of Applied Polymer Science 127.2 (2013): 1203-1210. Text
2. Droplet-Assisted Microfluidic Fabrication and Characterization of Multifunctional Polysaccharide Microgels Formed by Multicomponent Reactions. Polymers 10.10 (2018): 1055. Text
3. Peroxidase-Immobilized Porous Silica Particles for In Situ Formation of Peroxidase-Free Hydrogels with Attenuated Immune Responses, Acta Biomaterialia, 2018, doi: 10.1016/j.actbio.2018.09.054.
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