AC-PEG-SCM, MW 3.4k
Acrylate-PEG-SCM is a linear heterobifunctional PEG reagent with an Acrylate and an activated NHS ester. It is a useful crosslinking reagent with a PEG spacer. Acrylate can polymerize with UV light or radical initiator. SCM is one type of NHS esters, often called succinimidyl carboxyl methyl (SCM) ester. SCM is very reactive with primary amine to form a stable amide bond. Acrylate-PEG-SCM may be used to introduce an amine reactive functional group in crosslinked PEG hydrogel.
Molecular weight: MW of PEG was measured by MALDI-MS or GPC. PDI (polydispersity index) of our linear PEG is 1.02-1.05 with very narrow MW distribution. The number of repeating ethylene oxide units (CH2CH2O) or the degree of polymerization is calculated dividing the PEG MW by 44 (44 is the molecular mass of one repeating unit).
Solubility: Soluble in water and aqueous buffer, chloroform, methylene chloride, DMF, DMSO, and less soluble in alcohol, toluene. Not soluble in ether.
Density: PEG density is approximately 1.125 g/mL
Physical form: PEG products generally appear as white or off-white powder, and for very low MW linear PEG such as MW 1k or less, it may appear as wax-like, semi-solid material due to the low MW and the type of functional groups.
Storage condition: PEG product shall be stored in the original form as received in a freezer at -20C or lower for long term storage. Stock solution of PEG reagents that do not contain oxygen or moisture sensitive functional groups may be temporarily stored in a refrigerator or ambient temperature for multiple days. Stock solution should avoid repeated freeze-and-thaw cycles. See Documents section for detailed storage and handling conditions.
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2. Crosslinking Proteins to PEG Hydrogels – Injectable laminin-functionalized hydrogel for nucleus pulposus regeneration, Biomaterials, 2013 (34): 7381-7388, Text.
3. Crosslinking Proteins to PEG Hydrogels – Photocrosslinkable laminin-functionalized polyethylene glycol hydrogel for intervertebral disc regeneration, Acta Biomaterialia 10 (2014) 1102-1111, Text.
4. Bioartificial matrices for therapeutic vascularization. Proceedings of the National Academy of Sciences 107.8 (2010): 3323-3328. Text.
5. PEG-PCL Hydrogel and Conjugation of Proteins – Shape Memory RGD-Containing Networks: Synthesis, Characterization, and Application in Cell Culture, Macromol. Symp. 2011, 309/310, 162-172,Text.
6. N-cadherin is Key to Expression of the Nucleus Pulposus Cell Phenotype under Selective Substrate Culture Conditions, Scientific Reports 6, Article number: 28038 (2016), Text.
7. Design of Hydrogel Particle Morphology for Rapid Bioassays. Analytical Chemistry. 2018 Oct 19. Text.
8. Mechanosensitive transcriptional coactivators MRTF-A and YAP/TAZ regulate nucleus pulposus cell phenotype through cell shape, The FASEB Journal, 2019, doi: 10.1096/fj.201802725RRR
9. Interfacial Coating Method for Amine-Rich Surfaces using Poly(ethylene glycol) Diacrylate Applied to Bioprosthetic Valve Tissue Models, ACS Appl. Bio Mater. 2020, DOI: 10.1021/acsabm.9b00911
10. Preparation of Protein-Polymer Conjugates: Copolymerisation by RAFT, 2020, DOI: 10.1071/CH19514. Text.
11. Development of a library of laminin-mimetic peptide hydrogels for control of nucleus pulposus cell behaviors, J Tissue Eng. 2021 Jan-Dec; 12: 20417314211021220. Text.
12. Bioactive in situ crosslinkable polymer-peptide hydrogel for cell delivery to the intervertebral disc in a rat model, Acta Biomaterialia, 2021, 117-127, Text.
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