Acrylate-PEG-Amine is a linear heterobifunctional PEG reagent with an acrylate and an amine. It is a useful crosslinking reagent with a PEG spacer. Acrylate can polymerize with UV light or radical initiator, and amine can react with carboxylic acid or NHS ester. Acrylate-PEG-NH2 may be used to introduce an amine functional group in PEG hydrogel. The product is typically provided in the TFA or HCl salt form.
Molecular weight: MW of PEG was measured by MALDI-MS or GPC. PDI (polydispersity index) of our linear PEG is 1.02-1.05 with very narrow MW distribution. The number of repeating ethylene oxide units (CH2CH2O) or the degree of polymerization is calculated by dividing the PEG MW by 44 (44 is the molecular mass of one repeating unit).
Solubility: Soluble in water and aqueous buffer, chloroform, methylene chloride, DMF, DMSO, and less soluble in alcohol, toluene. Not soluble in ether.
Density: PEG density is approximately 1.125 g/mL
Physical form: PEG products generally appear as white or off-white powder, and for very low MW linear PEG such as MW 1k or less, it may appear as wax-like, semi-solid material due to the low MW and the type of functional groups.
Storage condition: PEG product shall be stored in the original form as received in a freezer at -20C or lower for long term storage. Stock solution of PEG reagents that do not contain oxygen or moisture sensitive functional groups may be temporarily stored in a refrigerator or ambient temperature for multiple days. Stock solution should avoid repeated freeze-and-thaw cycles. See Documents section for detailed storage and handling conditions.
1. Controlled and sustained delivery of siRNA/NPs from hydrogels expedites bone fracture healing, Biomaterials, Volume 139, September 2017, Pages 127-138, Text.
2. A biodegradable nanocapsule delivers a Cas9 ribonucleoprotein complex for in vivo genome editing, Nature Nanotechnology (2019), DOI: 10.1038/s41565-019-0539-2
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