Description
8-Arm PEG-Thiol is a multiarmed PEG derivative with thiol at each terminal of the eight arms. One hexaglycerol core connects all 8 arms through ether bonds. The reactive free thiol, SH, sulfhydryl, or mercapto selectively react with maleimide forming thioether bond. Thiol also PEGylates transition metal surface including gold, silver nanoparticles. PEG-SH can be easily air oxidized to form S-S disulfide bonds, which can be reversed with reducing agents. 8-Arm PEG-Thiol is a useful reagent for reversible PEGylation and forming PEG hydrogel.
Properties
Molecular weight: 8-Arm PEG MW refers to the MW of the entire PEG molecule. The MW of each arm is 1/8 of the MW indicated in the product name. MW of PEG was measured by MALDI-MS or GPC. PDI (polydispersity index) of our 8-Arm PEG is 1.02-1.06 with very narrow MW distribution. The number of repeating ethylene oxide units (CH2CH2O) or the degree of polymerization is calculated dividing the PEG MW by 44 (44 is the molecular mass of one repeating unit).
Solubility: Soluble in water and aqueous buffer, chloroform, methylene chloride, DMF, DMSO, and less soluble in alcohol, toluene. Not soluble in ether.
Density: PEG density is approximately 1.125 g/mL
Physical form: PEG products generally appear as white or off-white powder, and for certain special 8-arm PEGs, it may appear as wax-like, semi-solid material due to low MW and the type of functional groups.
Storage condition: PEG product shall be stored in the original form as received in a freezer at -20C or lower for long term storage. Stock solution of PEG reagents that do not contain oxygen or moisture sensitive functional groups may be temporarily stored in a refrigerator or ambient temperature for multiple days. Stock solution should avoid repeated freeze-and-thaw cycles. See Documents section for detailed storage and handling conditions.
References
1. Sustained micellar delivery via inducible transitions in nanostructure morphology, Nature Communications, volume 9, Article number: 624 (2018) doi:10.1038/s41467-018-03001-9, Text.
2. Method for Reversible fixation or selective lysis of cell using photocleavable polymer. U.S. Patent No. 20,150,148,243. 28 May 2015. Text.
3. Microfluidic fabrication of bioactive microgels for rapid formation and enhanced differentiation of stem cell spheroids. Acta Biomater. 2016 Apr 1; 34: 125–132. Text.
4. Sustained micellar delivery via inducible transitions in nanostructure morphology. Nature communications. 2018 Feb 12;9(1):624. Text.
5. Adhesive liposomes loaded onto an injectable, self-healing and antibacterial hydrogel for promoting bone reconstruction, NPG Asia Materials, volume 11, Article number: 81 (2019), Text.
6. 9. A role for mast cells in geographic atrophy, The FASEB Journal. 2020;00:1–15, DOI: 10.1096/fj.202000807R
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