8-Arm PEG-Alkyne, MW 40k
8-Arm PEG-Alkyne is a multiarmed PEG derivative with alkyne or acetylene at each terminal of the eight arms connected to one hexaglycerol core. PEG alkyne is for PEGylation via a copper-catalyzed click chemistry reaction with azide. Strained cyclooctyne used in copper-free click chemistry is available as catalog product or custom synthesis.
Molecular weight: 8-Arm PEG MW refers to the MW of the entire PEG molecule. The MW of each arm is 1/8 of the MW indicated in the product name. MW of PEG was measured by MALDI-MS or GPC. PDI (polydispersity index) of our 8-Arm PEG is 1.02-1.06 with very narrow MW distribution. The number of repeating ethylene oxide units (CH2CH2O) or the degree of polymerization is calculated dividing the PEG MW by 44 (44 is the molecular mass of one repeating unit).
Solubility: Soluble in water and aqueous buffer, chloroform, methylene chloride, DMF, DMSO, and less soluble in alcohol, toluene. Not soluble in ether.
Density: PEG density is approximately 1.125 g/mL
Physical form: PEG products generally appear as white or off-white powder, and for certain special 8-arm PEGs, it may appear as wax-like, semi-solid material due to low MW and the type of functional groups.
Storage condition: PEG product shall be stored in the original form as received in a freezer at -20C or lower for long term storage. Stock solution of PEG reagents that do not contain oxygen or moisture sensitive functional groups may be temporarily stored in a refrigerator or ambient temperature for multiple days. Stock solution should avoid repeated freeze-and-thaw cycles. See Documents section for detailed storage and handling conditions.
1. Anthony Atala et al, Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform, Scientific Report, 2017; 7: 8837, Text
2. A hydrogel bioink toolkit for mimicking native tissue biochemical and mechanical properties in bioprinted tissue constructs. Acta Biomaterialia (2015). Text.
3. Multi-tissue interactions in an integrated three-tissue organ-on-a-chip platform, Sci Rep. 2017; 7: 8837, Text.
4. Bioprinted trachea constructs with patient matched design, mechanical and biological properties, 2019, Biofabrication, 2019, doi: 10.1088/1758-5090/ab5354
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