4-Arm PEG-Vinylsulfone, or 4-Arm PEG-VS, is a multi-armed PEG reagent with four thiol reactive vinylsulfone (VS) groups. VS selectively reacts with free thiol, SH, sulfhydryl or mercapto groups for site specific PEGylation of peptide and proteins.
Molecular weight: 4-Arm PEG MW refers to the MW of the entire PEG molecule. The MW of each arm is 1/4 of the MW indicated in the product name. MW of PEG was measured by MALDI-MS or GPC. PDI (polydispersity index) of our 4-Arm PEG is 1.02-1.05 with very narrow MW distribution. The number of repeating ethylene oxide units (CH2CH2O) or the degree of polymerization is calculated dividing the PEG MW by 44 (44 is the molecular mass of one repeating unit).
Solubility: Soluble in water and aqueous buffer, chloroform, methylene chloride, DMF, DMSO, and less soluble in alcohol, toluene. Not soluble in ether.
Density: PEG density is approximately 1.125 g/mL.
Physical form: PEG products generally appear as white or off-white powder, and for very low MW 4-Arm PEG such as MW 2k, it may appear as wax-like, semi-solid material due to the low MW and the type of functional groups.
Storage condition: PEG product shall be stored in the original form as received in a freezer at -20C or lower for long term storage. Stock solution of PEG reagents that do not contain oxygen or moisture sensitive functional groups may be temporarily stored in a refrigerator or ambient temperature for multiple days. Stock solution should avoid repeated freeze-and-thaw cycles. See Documents section for detailed storage and handling conditions.
1. Enza Torino et al, PEGylated crosslinked hyaluronic acid nanoparticles designed through a microfluidic platform for nanomedicine, Future Medicine Ã¢â‚¬â€œ Nanomedicine, 2017, DOI: 10.2217/nnm-2017-0103, Text
2. PEGylated crosslinked hyaluronic acid nanoparticles designed through a microfluidic platform for nanomedicine, Nanomedicine,Â 2017, 12(18), doi: 10.2217/nnm-2017-0103 Text.
3.A layer-by-layer single-cell coating technique to produce injectable beating mini heart tissues via microfluidics, Biomacromolecules, 2019, DOI:10.1021/acs.biomac.9b00786
4. Gated Photoreactivity of Pyrene Copolymers in Multiresponsive Cross-Linked starPEG-Hydrogels, ACS Polym. AuÂ 2021, 1, 1
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