4-Arm PEG-OH is a multi-armed polyethylene glycol with hydroxyl groups at each terminal of the four arms. Pentaerythritol core is used in 4-arm PEG raw materials and derivatives. The indicated molecular weight of multi-arm PEG is the sum of the molecular weights of all the arms. 4-Arm PEG-OH can be used to prepare functional PEG reagents or in sol-gel chemistry to make silica-related hydrogel.
Molecular weight: 4-Arm PEG MW refers to the MW of the entire PEG molecule. The MW of each arm is 1/4 of the MW indicated in the product name. MW of PEG was measured by MALDI-MS or GPC. PDI (polydispersity index) of our 4-Arm PEG is 1.02-1.05 with very narrow MW distribution. The number of repeating ethylene oxide units (CH2CH2O) or the degree of polymerization is calculated dividing the PEG MW by 44 (44 is the molecular mass of one repeating unit).
Solubility: Soluble in water and aqueous buffer, chloroform, methylene chloride, DMF, DMSO, and less soluble in alcohol, toluene. Not soluble in ether.
Density: PEG density is approximately 1.125 g/mL.
Physical form: PEG products generally appear as white or off-white powder, and for very low MW 4-Arm PEG such as MW 2k, it may appear as wax-like, semi-solid material due to the low MW and the type of functional groups.
Storage condition: PEG product shall be stored in the original form as received in a freezer at -20C or lower for long term storage. Stock solution of PEG reagents that do not contain oxygen or moisture sensitive functional groups may be temporarily stored in a refrigerator or ambient temperature for multiple days. Stock solution should avoid repeated freeze-and-thaw cycles. See Documents section for detailed storage and handling conditions.
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8. The impact of adhesion peptides within hydrogels on the phenotype and signaling of normal and cancerous mammary epithelial cells. Biomaterials 33.13 (2012): 3548-3559. Text.
9. Dual redox-responsive PEG-PPS-cRGD self-crosslinked nanocapsules for targeted chemotherapy of squamous cell carcinoma. RSC Advances. 2017;7(84):53552-62. Text.
10. Dynamic Model Metallo-Supramolecular Dual-Network Hydrogels with Independently Tunable Network Crosslinks, JOURNAL OF POLYMER SCIENCE 2020, 58, 330-342, Text
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12. An injectable double cross-linked hydrogel adhesive inspired by synergistic effects of mussel foot proteins for biomedical application, Colloids and Surfaces B: Biointerfaces, 2021, 111782, Text.
13. Induction of dormancy by confinement: An agarose-silica biomaterial for isolating and analyzing dormant cancer cells, Text.
14. Poly(ethylene glycol) Hydrogel Crosslinking Chemistries Identified via Atmospheric Solids Analysis Probe Mass Spectrometry, Macromolecules, 2021, 54, 17
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