4-Arm PEG-DSPE has a phospholipid of saturated C18 stearoyl fatty acid (octadecanoic acid) at each of the four arms. DSPE: 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine, CAS: 1069-79-0. Other PEG lipid reagents including arachidic, palmitic, myristic, lauric, and capric acid, and unsaturated fatty acids are available via custom synthesis. PEG-phospholipid forms stealth liposome or micelle for targeted drug delivery and solubility enhancement.
Molecular weight: 4-Arm PEG MW refers to the MW of the entire PEG molecule. The MW of each arm is 1/4 of the MW indicated in the product name. MW of PEG was measured by MALDI-MS or GPC. PDI (polydispersity index) of our 4-Arm PEG is 1.02-1.05 with very narrow MW distribution. The number of repeating ethylene oxide units (CH2CH2O) or the degree of polymerization is calculated dividing the PEG MW by 44 (44 is the molecular mass of one repeating unit).
Solubility: Soluble in water and aqueous buffer, chloroform, methylene chloride, DMF, DMSO, and less soluble in alcohol, toluene. Due to the large hydrophobic groups in 4-arm PEG-DSPE, this reagent is less soluble in aqueous solution and has enhanced solubility in ether.
Density: PEG density is approximately 1.125 g/mL.
Physical form: PEG products generally appear as white or off-white powder, and for very low MW 4-Arm PEG such as MW 2k, it may appear as wax-like, semi-solid material due to the low MW and the type of functional groups.
Storage condition: PEG product shall be stored in the original form as received in a freezer at -20C or lower for long term storage. Stock solution of PEG reagents that do not contain oxygen or moisture sensitive functional groups may be temporarily stored in a refrigerator or ambient temperature for multiple days. Stock solution should avoid repeated freeze-and-thaw cycles. See Documents section for detailed storage and handling conditions.
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