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mPEG-Norbornene

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mPEG-Norbornene

mPEG Norbornene
PSB-908
mPEG-Norbornene, MW 550
PSB-902
mPEG-Norbornene, MW 2k
PSB-905
mPEG-Norbornene, MW 20k
PSB-901
mPEG-Norbornene, MW 1k
PSB-903
mPEG-Norbornene, MW 5k
PSB-907
mPEG-Norbornene, MW 40k
PSB-906
mPEG-Norbornene, MW 30k
PSB-904
mPEG-Norbornene, MW 10k

Description

mPEG-Norbornene is a linear monofunctional PEG with a reactive norbornene group. mPEG-Norbornene is useful to perform thiol-ene reaction to prepare hydrogels and other biocompatible materials. Cross-linked hydrogels are through orthogonal reactions between multi-functional norbornene-modified macromers (e.g., poly(ethylene glycol), hyaluronic acid) and sulfhydryl-containing linkers. Common thiol linkers include dithiothreitol, PEG-dithiol, bis-cysteine peptides, 4-arm PEG-SH and 8-arm PEG-thiol. Norbornene conjugation to PEG is through stable amide bonds in our standard catalog products. Attachment of norbornene to PEG via hydrolytic ester bonds is also available through custom synthesis. Norbornene is typically a mixture of endo and exo isomers, predominantly endo isomer. Both isomers have almost identical reactivity in thiol-ene reactions.

Properties

Molecular weight: MW of PEG was measured by MALDI-MS or GPC. PDI (polydispersity index) of our linear PEG is 1.02-1.05 with very narrow MW distribution. The number of repeating ethylene oxide units (CH2CH2O) or the degree of polymerization is calculated dividing the PEG MW by 44 (44 is the molecular mass of one repeating unit).

Solubility: Soluble in water and aqueous buffer, chloroform, methylene chloride, DMF, DMSO, and less soluble in alcohol, toluene. Not soluble in ether.

Density: PEG density is approximately 1.125 g/mL

Physical form: PEG products generally appear as white or off-white powder, and for very low MW linear PEG such as MW 1k or less, it may appear as wax-like, semi-solid material due to the low MW and the type of functional groups.

Storage condition: PEG product shall be stored in the original form as received in a freezer at -20C or lower for long term storage. Stock solution of PEG reagents that do not contain oxygen or moisture sensitive functional groups may be temporarily stored in a refrigerator or ambient temperature for multiple days. Stock solution should avoid repeated freeze-and-thaw cycles. See Documents section for detailed storage and handling conditions.

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