Properties
Chondroitin sulfate chains are unbranched polysaccharides containing two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc). Chondroitin sulfate from terrestrial animals is almost exclusively composed of non-sulfated (O) and monosulfated (A and C) units, while in marine species the proportion of disulfated (D and E) units is higher. Chondroitin sulfate A is sulfated at carbon 4 of the N-acetylgalactosamine (GalNAc) sugar, also called chondroitin-4-sulfate
Chondroitin sulfate is highly soluble in water.
References
1. Harnessing the Versatility of Bacterial Collagen to Improve the Chondrogenic Potential of Porous Collagen Scaffolds, Adv Healthc Mater. 2016;5(13):1656-66, Text.
2. Enhanced articular cartilage by human mesenchymal stem cells in enzymatically mediated transiently RGDS-functionalized collagen-mimetic hydrogels, Acta Biomaterialia, 2017, 51, 75-88, Text.
3. Chondroitin sulfate inhibits secretion of TNF and CXCL8 from human mast cells stimulated by IL33. BioFactors. 2018 Dec 6. Text.
4. Developing a multivariate prediction model of antibody features associated with protection of malaria-infected pregnant women from placental malaria, eLife 2021;10:e65776, Text.
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