Description
Chondroitin Sulfate Fluorescein is a fluorescently labeled polysaccharide polymer. Chondroitin Sulfate is labeled with fluorescein (FITC), Ex/Em wavelength 494/518 nm. Purity: >95% powder. Degree of substitution: 1 mol % substitution and at least one dye molecule per polymer. Chondroitin sulfate with other fluorescent dyes or biomolecular probes may be offered through custom synthesis.
Properties
Chondroitin sulfate chains are unbranched polysaccharides containing two alternating monosaccharides: D-glucuronic acid (GlcA) and N-acetyl-D-galactosamine (GalNAc). Chondroitin sulfate from terrestrial animals is almost exclusively composed of non-sulfated (O) and monosulfated (A and C) units, while in marine species the proportion of disulfated (D and E) units is higher. Chondroitin sulfate A is sulfated at carbon 4 of the N-acetylgalactosamine (GalNAc) sugar, also called chondroitin-4-sulfate
Chondroitin sulfate is highly soluble in water.
References
1. Harnessing the Versatility of Bacterial Collagen to Improve the Chondrogenic Potential of Porous Collagen Scaffolds, Adv Healthc Mater. 2016;5(13):1656-66, Text.
2. Enhanced articular cartilage by human mesenchymal stem cells in enzymatically mediated transiently RGDS-functionalized collagen-mimetic hydrogels, Acta Biomaterialia, 2017, 51, 75-88, Text.
3. Chondroitin sulfate inhibits secretion of TNF and CXCL8 from human mast cells stimulated by IL33. BioFactors. 2018 Dec 6. Text.
4. Developing a multivariate prediction model of antibody features associated with protection of malaria-infected pregnant women from placental malaria, eLife 2021;10:e65776, Text.
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