Catalog No. : HA-351
Product Name : Hyaluronate Hydrazide, MW 10k
Description :

Hyaluronic Acid is functionalized with hydrazide groups using a short linker adipic acid dihydrazide (ADH). Purity: >95% powder. Degree of substitution (DoD): 5 mol % substitution unless the DoS is specifically noted in the catalog number. For example, HA-352-50% means 50% DoS for this particular product. Hydrazide is a reactive group specific for aldehydes resulting in acyl hydrazone linkages, and can be used in the linking of glycoproteins or carbohydrates in a site specific fashion following periodate oxidation. Hydrazide coupling may be performed at relatively low pH such as 5.0 to avoid competition reaction by primary amines. HA-Hydrazide with higher or lower hydrazide substitution ratio (e.g. 1% and 10%) may be offered through custom synthesis service.

The Hydrazide substitution or labeling ratio is the percentage of HA disaccharide monomers that are functionalized with Hydrazide groups. You may calculate the number of Hydrazide by 1) dividing the MW of HA by the MW of one disaccharide monomer to derive the number of disaccharide monomers in HA; 2) then multiple the number of disaccharide monomers by the labeling ratio to get the number of Hydrazide in each HA polymer.

Literature:

1. A hyaluronic acid conjugate engineered to synergistically and sequentially deliver gemcitabine and doxorubicin to treat triple negative breast cancer, Journal of Controlled Release, 2017, doi 10.1016/j.jconrel.2017.08.016, Text.

2. Functionalized Derivatives of Hyaluronic Acid Oligosaccharides: Drug Carriers and Novel Biomaterials, Bioconjugate Chemistry, 1994,5(4):339–347 2) Hyaluronic acid based scaffolds for tissue engineering—A review, Carbohydrate Polymers 2013, 92(2):1262– 1279.

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