Catalog No. : HA-324
Product Name : Hyaluronate Amine, MW 750k
Description :

Hyaluronic Acid is functionalized or derivatized with amine groups. Amine groups are conjugated to HA through an amide bond. Purity: >95% powder. Degree of substitution (DoS): 5 mol %; unless specifically noted in the catalog number. For example, HA-323-50% means that the DoS for amine is 50%. HA-Amine derivatives with lower or higher amine NH2 substitution ratio (e.g. 1% and 10%) may be offered through custom synthesis service.

The amine substitution or labeling ratio is the percentage of HA disaccharide monomers that are functionalized with amine groups. You may calculate the number of amine by 1) dividing the MW of HA by the MW of one disaccharide monomer to derive the number of disaccharide monomers in HA; 2) then multiple the number of disaccharide monomers by the labeling ratio to get the number of amine in each HA polymer.

References: 1. Chemical modification of hyaluronic acid by carbodiimides, Bioconjugate chemistry, 1991, 2(4):232-41.

2. Hyaluronic acid based scaffolds for tissue engineering—A review, Carbohydrate Polymers 2013, 92(2):1262– 1279

3. Induction of Cancer Cell Death by Hyaluronic Acid-Mediated Uptake of Cytochrome C. J Nanomed Nanotechnol 6.316 (2015): 2. Text.

4. Bio-orthogonally crosslinked hyaluronate-collagen hydrogel for suture-free corneal defect repair. Biomaterials, 2020, 120176. DOI: 10.1016/j.biomaterials.2020.120176

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