Description
Mono-Biotin Labeled Hyaluronan has one single biotin molecule at the reducing end of HA polymer. Purity: >95% lyophilized powder. Degree of substitution: one biotin molecule per HA polymer. Hyaluronic Acid synonyms: HA, hyaluronate, hyaluronan.
Properties
Name and Source: Hyaluronic acid (HA, Hyaluronan, Hyaluronate) is an anionic, non-sulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. CAS# 9004-61-9. Our HA products are produced via microbial fermentation. See Documents section for details.
Appearance: White, lyophilized powder, except dye-labeled HA reagents.
Solubility: Soluble in water and the solubility data varies with MW. Higher MW results in lowered solubility. Typically solubility ranges 5-50 mg/mL, that is, 0.5%-5%. Buffered solution at pH >6 enhances solubility due to deprotonation of carboxylic acid groups and formation of carboxylate salts. HA derivatives with hydrophobic groups will lower the solubility in water, and adding alcohol or DMSO to an alcohol-water or DMSO-water mixture can dramatically improve the solubility up to 200 mg/mL (20%).
References
1. Structural basis of laminin binding to the LARGE glycans on dystroglycan, Nature Chemical Biology12,810(2016), Text.
2. Clearance kinetics of biomaterials affects stem cell retention and therapeutic efficacy. Biomacromolecules 15.2 (2014): 564-573. Text.
3. Biotinylated hyaluronic acid: a new tool for probing hyaluronate-receptor interactions. Bioconjug Chem., 1994, 5(4):370-2.
4. 3. Single-molecule mechanical measurements of the hyaluronan-aggrecan bottle brush, Biomolecules, 2019, arXiv:1910.13576
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