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Hyaluronate Azide, MW 1,000k

Hyaluronate Azide, MW 1,000k

Catalog No: HA-1905
Product Name: Hyaluronate Azide, MW 1,000k
In Stock: Yes
SKUProduct Name
HA-1905-500mg
Hyaluronate Azide, MW 1,000k - 500mg
$750.00
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HA-1905-100mg
Hyaluronate Azide, MW 1,000k - 100mg
$250.00
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HA-1905-1g
Hyaluronate Azide, MW 1,000k - 1g
$1,150.00
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+
Interested in Bulk Orders? Please contact us here

Description

Hyaluronic Acid azide is a functionalized hyaluronic acid polymer for click chemistry with alkyne or DBCO. The standard azide labeling ratio or degree of substitution (DoS) is 5%. The labeling ratio means that 5% of the disaccharide monomers (1 out of every 20) has azide groups. If you require a different azide labeling ratio (from 1% to 50%), we can custom synthesize it for you. Special DoS other than 5% is also listed to order and the DoS% is indicated in the catalog number and product name. Hyaluronic acid synonyms: HA, hyaluronate, hyaluronan.

Properties

Name and Source: Hyaluronic acid (HA, Hyaluronan, Hyaluronate) is an anionic, non-sulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. CAS# 9004-61-9. Our HA products are produced via microbial fermentation. See Documents section for details.

Appearance: White, lyophilized powder, except dye-labeled HA reagents.

Solubility: Soluble in water and the solubility data varies with MW. Higher MW results in lowered solubility. Typically solubility ranges 5-50 mg/mL, that is, 0.5%-5%. Buffered solution at pH >6 enhances solubility due to deprotonation of carboxylic acid groups and formation of carboxylate salts. HA derivatives with hydrophobic groups will lower the solubility in water, and adding alcohol or DMSO to an alcohol-water or DMSO-water mixture can dramatically improve the solubility up to 200 mg/mL (20%).

Degree of Substitution (DoS): The standard DoS is 5% by default. Product variants with special DoS other than 5% is indicated in the product name and catalog number. For example, HA-301-30% means that the DoS is 30% for this particular product.

The substitution or labeling ratio is the percentage of HA disaccharide monomers that are functionalized with the functional groups. You may calculate the number of functional groups in each HA polymer chain by 1) dividing the MW of HA by the MW of one disaccharide monomer to derive the number of disaccharide monomers in HA; 2) then multiple the number of disaccharide monomers by the labeling ratio or DoS to get the number of functional groups in each HA polymer. See Documents section for details.

References

Click here  to view an expanded list of hundreds of publications citing Creative PEGWorks products.

Documents

 Technical Information Hyaluronic Acid Products
 SDS of Hyaluronate Azide

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