Hyaluronate AMCA, MW 750k

Hyaluronate AMCA, MW 750k

Catalog No:HA-903
Product Name:Hyaluronate AMCA, MW 750k
In Stock: Yes
SKUProduct Name
HA-903-50mg
Hyaluronate AMCA, MW 750k - 50mg
$750.00
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+
HA-903-100mg
Hyaluronate AMCA, MW 750k - 100mg
$1,150.00
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+
HA-903-10mg
Hyaluronate AMCA, MW 750k - 10mg
$250.00
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+
Interested in Bulk Orders? Please contact us here

Description

Hyaluronic Acid is labeled with AMCA (aminomethyl coumarin acetate). AMCA is a blue fluorescent dye (Excitation: 345-350 nm, Emission: 440-460 nm). Purity: >95% lyophilized powder. Degree of substitution: 1 mol % substitution and at least one dye molecule per HA polymer.

Properties

Name and Source: Hyaluronic acid (HA, Hyaluronan, Hyaluronate) is an anionic, non-sulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. CAS# 9004-61-9. Our HA products are produced via microbial fermentation. See Documents section for details.

Appearance: Lyophilized powder. The color depends on the color of the dye and the dye labeling ratio.

Solubility: Soluble in water and the solubility data varies with MW. Higher MW results in lowered solubility. Typically solubility ranges 5-50 mg/mL, that is, 0.5%-5%. Buffered solution at pH >6 enhances solubility due to deprotonation of carboxylic acid groups and formation of carboxylate salts. HA derivatives with hydrophobic groups will lower the solubility in water, and adding alcohol or DMSO to an alcohol-water or DMSO-water mixture can dramatically improve the solubility up to 200 mg/mL (20%).

Degree of Substitution (DoS): The standard DoS is 1% by default. Product variants with special DoS other than 1% is indicated in the product name and catalog number. For example, HA-635-2% means that the DoS is 2% for this particular product.

The substitution or labeling ratio is the percentage of HA disaccharide monomers that are functionalized with the functional groups. You may calculate the number of functional groups in each HA polymer chain by 1) dividing the MW of HA by the MW of one disaccharide monomer to derive the number of disaccharide monomers in HA; 2) then multiple the number of disaccharide monomers by the labeling ratio or DoS to get the number of functional groups in each HA polymer. See Documents section for details.

References

1) Aminomethyl coumarin acetic acid: a new fluorescent labelling agent for proteins. Histochem J. 1986, 18(9):497-9.

2) Hyaluronic acid: a natural biopolymer with a broad range of biomedical and industrial applications, Biotechnology Letters, 2007, 29(1): 17-25

Click here to view an expanded list of hundreds of publications citing Creative PEGWorks products.

Documents

 Technical Information Hyaluronic Acid Products
 SDS of Hyaluronate AMCA

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